Polo-like kinases: positive regulators of cell division from start to finish
References (66)
- et al.
Cell-cycle control: polo-like kinases join the outer circle
Trends Cell Biol
(1997) - et al.
Identification by targeted differential display of an immediate early gene encoding a putative serine/threonine kinase
J Biol Chem
(1995) - et al.
Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas
J Biol Chem
(1996) - et al.
Plk is a functional homolog of Saccharomyces cerevisiae Cdc5, and elevated Plk activity induces multiple septation structures
Mol Cell Biol
(1997) - et al.
GFP tagging reveals human Polo-like kinase 1 at the kinetochore/centromere region of mitotic chromosomes
Chromosoma
(1998) - et al.
Pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis
Genes Dev
(1998) - et al.
The mitotic peptidyl prolyl isomerase, Pin1, interacts with Cdc25 and Plx1
EMBO J
(1998) - et al.
S-phase feedback control in budding yeast independent of tyrosine phosphorylation of p34cdc28
Nature
(1992) - et al.
How proteolysis drives the cell cycle
Science
(1996) - et al.
The control of septum formation in fission yeast
Genes Dev
(1997)
What does Mos do in oocytes and somatic cells?
Bioessays
(1997)
Characterisation of a polo-like protein kinase gene homologue from an evolutionary divergent eukaryote, Trypanosoma brucei
Gene
(1998)
Polo kinase: the choreographer of the mitotic stage?
J Cell Biol
(1996)
polo, a mitotic mutant of Drosophila displaying abnormal spindle poles
J Cell Sci
(1988)
Identification of an early-growth-response gene encoding a novel putative protein kinase
Mol Cell Biol
(1992)
Expression and phosphorylation of fibroblast-growth-factor-inducible kinase (Fnk) during cell-cycle progression
Biochem J
(1998)
Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions
J Biol Chem
(1997)
Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function
J Cell Biol
(1995)
Polo-like kinase is a cell cycle-regulated kinase activated during mitosis
J Biol Chem
(1995)
Plk is an M-phase-specific protein kinase and interacts with a kinesin- like protein, CHO1/MKLP-1
Mol Cell Biol
(1995)
On the regulation and function of human polo-like kinase 1 (PLK1): effects of overexpression on cell cycle progression
Biochem Biophys Res Commun
(1997)
A conserved mitotic kinase active at late anaphase-telophase in syncytial Drosophila embryos
Nature
(1993)
The Drosophila POLO kinase localises to multiple compartments of the mitotic apparatus and is required for the phosphorylation of MPM2 reactive epitopes
J Cell Sci
(1998)
The conserved mitotic kinase polo is regulated by phosphorylation and has preferred microtubule-associated substrates in Drosophila embryo extracts
EMBO J
(1996)
The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs
J Cell Sci
(1998)
Activated polo-like kinase Plx1 is required at multiple points during mitosis in Xenopus laevis
Mol Cell Biol
(1998)
A novel role for Cdc5p in DNA replication
Mol Cell Biol
(1997)
The polo-related kinase cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae
Curr Biol
(1998)
The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae
EMBO J
(1998)
Role of fission yeast polo kinase in selecting the site of cell division
J Cell Biol
(1998)
Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk
Proc Natl Acad Sci USA
(1998)
Active and inactive protein kinases: structural basis for regulation
Cell
(1996)
Purification and molecular cloning of Plx1, a Cdc25-stimulatory kinase from Xenopus egg extracts
Science
(1996)
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2021, European Journal of Medicinal ChemistryActivating transcription factor 6 (ATF6) negatively regulates Polo-like kinase 4 expression via recruiting C/EBPβ to the upstream-promoter during ER stress
2020, Biochimica et Biophysica Acta - Gene Regulatory MechanismsTherapeutic potential of PLK1 inhibition in triple-negative breast cancer
2019, Laboratory InvestigationMCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate
2019, Acta Pharmaceutica Sinica BCitation Excerpt :PLK1 is a member of the Polo-like kinase family1. It is one of the key main regulators of cell cycle division2. PLK1 acts in the M phase of the cell cycle through activation of the cyclin dependent kinase 1 (CDK1)–cyclin B complex3.
Copyright © 1998 Published by Elsevier Ltd.