Microcystic adnexal carcinoma: Collaborative series review and update☆,☆☆,★
Section snippets
MATERIAL AND METHODS
The medical records of 11 patients with MAC treated at the New York University Medical Center (P. R.) and the University of Tennessee Medical Center (R. A.) by Mohs micrographic surgery between 1986 and 1997 were reviewed. In each case, histologic diagnosis was confirmed by a dermatopathologist on the basis of sectioned, paraffin-embedded biopsy specimens stained with hematoxylin and eosin.
Mohs surgical excisions were performed and followed by sectioning and mapping of the tissue layer. After
RESULTS
The overall age of the patients ranged from 15 to 83 years (median, 63; mean, 62 years). The female-to-male ratio was 3.5:2. Tumors were located primarily on the head and neck area. Two of the patients experienced MAC at sites of previous radiotherapy. Of the 11 patients, 9 had primary tumor, and 2 presented with recurrence of MAC after primary excision. Tissue sections of all patients demonstrated tumor spreading several centimeters laterally beyond clinically apparent tumor tissue. The
DISCUSSION
MAC occurs predominantly on the head and neck, particularly in the centrofacial region. Involvement of the ear has been reported only twice previously,2, 3 and there are 3 cases of scalp involvement in the literature.4, 5, 6 Of the 105 cases reported in the English language literature (including our 11 cases), the median age of presentation was 56 years. Of these cases, the sex distribution was approximately equal, 54 (51%) occurring in men and 51 (49%) occurring in women. This neoplasm occurs
References (35)
- et al.
Microcystic adnexal carcinoma of the skin
J Am Acad Dermatol
(1993) - et al.
Microcystic adnexal carcinoma
J Am Acad Dermatol
(1993) - et al.
Microcystic adnexal carcinoma
J Am Acad Dermatol
(1984) - et al.
Microcystic adnexal carcinoma: report of a case
J Oral Maxillofac Surg
(1995) - et al.
Squamous cell carcinoma of the skin (excluding lip and oral mucosa)
J Am Acad Dermatol
(1992) - et al.
Microcystic adnexal carcinoma: a distinct clinicopathologic entity
Cancer
(1982) - et al.
Combined adnexal tumor of the skin
Arch Dermatol
(1984) - et al.
Pathologic quiz case 1
Arch Otolaryngol Head Neck Surg
(1995) - et al.
Microcystic adnexal carcinoma of the scalp
J Dermatol Surg Oncol
(1989) - et al.
Microcystic adnexal carcinoma
First reported case in a black patient
Dermatol Surg
(1998)
Bone marrow invasion of microcystic adnexal carcinoma
Ann Otol Rhinol Laryngol
Microcystic adnexal carcinoma
Microcystic adnexal carcinoma: an unpredictable aggressive neoplasm
Ann Plast Surg
Microcystic adnexal carcinoma (sclerosing sweat duct carcinoma)
South Med J
Radiation induced tumors: human experience. Special report No. 6
Br J Radiol
Basal cell carcinoma in young patients after irradiation for childhood malignancy
Med Pediatr Oncol
Acute lymphoblastic leukemia
N Engl J Med
Cited by (131)
Systematic review of Mohs micrographic surgery in children: Identifying challenges and practical considerations for successful application
2021, Journal of the American Academy of DermatologyCitation Excerpt :Fig 1 shows the article identification and review process. The characteristics of the 87 articles meeting inclusion criteria are summarized in Table I.4-90 Of the 87 included studies, there were 31 retrospective studies, 1 prospective study, 17 case series, and 38 case reports.
Microcystic adnexal carcinoma—diagnostic criteria and therapeutic methods: case report and review of the literature
2018, International Journal of Oral and Maxillofacial SurgeryUpdate on Malignant Sweat Gland Tumors
2017, Surgical Pathology ClinicsMicrocystic Adnexal Carcinoma of the Face Treated With Definitive Chemoradiation: A Case Report and Review of the Literature
2020, Advances in Radiation OncologyCitation Excerpt :Patients are generally asymptomatic and may present years after initial development of the skin lesion.7,8 Some develop ulceration or paresthesia if there is perineural invasion (PNI).5,9 Despite its subtle clinical appearance, MAC is a locally aggressive and infiltrative tumor and commonly presents with extensive subclinical involvement and PNI,4,6,10 although lymph node involvement and distant metastasis are rare.2
Periocular Microcystic Adnexal Carcinoma: A Case Report and a Major Review
2023, Ophthalmic Plastic and Reconstructive SurgeryDermatologic Mimickers of Breast Lesions Arising in the Breast Skin, Subcutis, or Axilla
2022, A Comprehensive Guide to Core Needle Biopsies of the Breast, Second Edition
- ☆
From the Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York,a and the Division of Dermatology, University of Tennessee Medical Center, Memphis.b
- ☆☆
Reprint requests: Perry Robins, MD/Paul Friedman, MD, 530 1st Ave, Suite 7H, New York, NY 10016.
- ★
0190-9622/99/$8.00 + 0 16/1/99387