Elsevier

Ophthalmology

Volume 89, Issue 11, November 1982, Pages 1213-1219
Ophthalmology

Optic Glioma: Long-term Follow-up of 85 Histopathologically Verified Cases

https://doi.org/10.1016/S0161-6420(82)34650-3Get rights and content

Abstract

Eighty-five cases of histologically verified gliomas of the optic nerve or chiasm were studied retrospectively. Patient survival was analyzed according to location of tumor, treatment received, presence of neurofibromatosis, and degree of histologic anaplasia. Thirty-three patients had optic nerve tumors, and 52 had tumors involving the chiasm. Follow-up ranged from 6 days to 43 7 years. Of the 33 patients with optic nerve tumors, 28 (85%) survived a mean duration of 17 years, and survival was significantly associated with completeness of surgical excision. Twenty-three of the 52 patients (44%) with chiasmal tumors survived a mean duration of 19 years. Survival among patients with chiasmal tumors was unrelated to therapy received and was affected adversely by concomitant involvement of adjacent brain structures. The presence of neurofibromatosis conferred a protective benefit to patients with chiasmal tumors. No other significant factors could be statistically identified to influence the prognosis of patients with optic gliomas.

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Dr. Rush is now with the University of South Florida College of Medicine, Tampa, Florida.

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