Outcome of patients with periocular sebaceous gland carcinoma with and without conjunctival intraepithelial invasionHistorical image☆
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Patients and methods
A computerized search was made of the medical records of all patients diagnosed with sebaceous gland carcinoma of the eyelids at the Oncology Service of Wills Eye Hospital, Philadelphia, Pennsylvania, between August 1979 and April 2000. There were 25 patients (25 eyes) identified who had sebaceous gland carcinoma of the eyelid, and all were included in this analysis.
The data from previous evaluations elsewhere were collected, including patient age at initial presentation (years), initial
Results
The demographic features of the 25 patients with sebaceous gland carcinoma are shown in Table 1. The mean age of the patients was 65 years (range, 17–90 years). There were 18 women (72%) and 7 men (28%), all of whom were white. No patients showed systemic Muir-Torre syndrome.12 Three patients (12%) had received prior facial external beam radiation therapy, one for pubertal acne and two for retinoblastoma. The median age at presentation in group A was 73 years (range, 33–87 years), and in group
Discussion
Sebaceous gland carcinoma displays intraepithelial conjunctival (pagetoid) invasion in 40% to 80% of cases.6, 7, 13 In our series, 11 patients (46%) had conjunctival intraepithelial invasion (group A). We found the demographic features of sebaceous gland carcinoma in our series to be comparable with previous reports. This tumor has been reported to show more prevalence in females with a female-to-male ratio of approximately 1.7 to 2.87, 10 and an average age at presentation of 60 to 69 years.2,
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Adnexal neoplasms of the eye
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2019, The Lancet OncologyCitation Excerpt :Pagetoid spread was present in 208 (24%) of 870 cases. Pagetoid tumours were more likely than non-pagetoid tumours to be poorly differentiated,14 recurrent,15 and require orbital exenteration;15,16 pagetoid tumours were also at higher risk for metastasis.17,18 For extraocular sebaceous carcinoma, positive immunohistochemical markers, as reported in a total of 38 studies, included nuclear factor XIIIa (AC-1A1), EMA (positive in squamous cell carcinoma), cytokeratin AE1 and AE3 (positive in squamous cell carcinoma), androgen receptor, adipophilin, and perilipin.
Mohs micrographic surgery for eyelid sebaceous carcinoma: A multicenter cohort of 360 patients
2019, Journal of the American Academy of DermatologyMohs micrographic surgery versus wide local excision for sebaceous adenocarcinoma of the eyelid: Analysis of a national database
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Supported by Department of Ophthalmology, Chang Gung Memorial Hospital, Taipei, Taiwan (ANC); Magrabi Eye Hospital, Cairo, Egypt (HK); Macula Foundation, New York, New York (CLS); Paul Kayser International Award of Merit in Retina Research, Houston, Texas (JAS); and the Eye Tumor Research Foundation, Philadelphia, Pennsylvania (CLS).