Cell
Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death
References (50)
- et al.
Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter
Gene
(1987) - et al.
Neurotrophin-5: a novel neutrophic factor that activates trk and trkB
Neuron
(1991) Keeping track of neutrophin receptors
Cell
(1991)Neurotrophin receptors: a window into neuronal differentiation
Neuron
(1992)- et al.
TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor
Cell
(1991) - et al.
Evolutionary studies of the nerve growth family reveal a novel member abundantly expressed in Xenopus ovary
Neuron
(1991) - et al.
Similarities and differences in the way neutrophins interact with the Trk receptors in neuronal and nonneuronal cells
Neuron
(1993) - et al.
The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain
Cell
(1990) - et al.
The trk proto-oncogene encodes a receptors for nerve growth factor
Cell
(1991) - et al.
The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
Cell
(1991)
The trkB tyrosine protein kinase is a receptor for neurotrophin-4
Neuron
Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo
Neuron
trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3
Cell
Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system
Cell
The nerve growth factor family of receptors
Trends Neurosci.
Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system
Neuroscience
Early regional variations in motoneuron numbers arise by differential proliferation in the chick embryo spinal cord
Dev. Biol.
Binding of brain-derived neurotrophic factor to the nerve growth factor receptor
Neuron
The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
Cell
trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor
Cell
The rat trkC locus encodes multiple neurogenic receptors that exhibit differential responses to neurotrophin-3 in PC12 cells
Neuron
Alternative forms of rat TrkC with different functional capabilities
Neuron
The duration of neurotrophic factor independence in early sensory neurons is matched to the time course of target field innervation
Neuron
Estimation of nuclear populations from microtome sections
Anat. Rec.
Nerve growth factor: a tale of two receptors
Oncogene
Cited by (602)
Oncogenic fusions: Targeting NTRK
2024, Critical Reviews in Oncology/HematologyChemogenetic inhibition of TrkB signalling reduces phrenic motor neuron survival and size
2023, Molecular and Cellular NeuroscienceGrowth factors and molecular-driven plasticity in neurological systems
2023, Handbook of Clinical NeurologyRoles of Trk receptors, tyrosine kinase receptors for neurotrophins, in the developing CNS
2023, Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric DisordersThe endocytosis, trafficking, sorting and signaling of neurotrophic receptors
2023, Progress in Molecular Biology and Translational ScienceDirected mechanisms for apical dendrite development during neuronal polarization
2022, Developmental BiologyCitation Excerpt :Many of these factors may exert their action in neuronal polarization by regulating the levels of cAMP and cGMP in developing neurons (Cheng et al., 2011b; Gao et al., 2003; Ming et al., 1997; Nishiyama et al., 2011; Polleux et al., 2000; Shelly et al., 2007, 2010; Szczurkowska et al., 2022; Togashi et al., 2008; Wang and Malbon, 2003). Despite their demonstrated role in neuronal polarization in vitro, no axon/dendrite formation defects were detected in mice with targeted deletion of genes for NGF (Crowley et al., 1994) and BDNF (Jones et al., 1994), or their respective receptors TrkA (Smeyne et al., 1994) and TrkB (Klein et al., 1993). The involvement of multiple factors and their coordinated actions may account for the observations that the disruption of the signaling of a single extracellular cue results in only subtle polarity defects in mammalian neurons in vivo.
- †
Present address: Differentiation Program, European Molecular Biology Laboratory, 69012 Heidelberg, Federal Republic of Germany.