Adult UrologyProstate cancer in the post-transplant population
Section snippets
Material and methods
Between January 1991 and December 1995, 2446 patients underwent solid organ transplantation at the University of Pittsburgh Medical Center. We examined the computerized case records of these patients to identify those with prostate cancer diagnosed after organ transplantation. All patients with a diagnosis of prostate cancer before transplantation or between one failed transplant and the next were eliminated. Only patients who first received the diagnosis of the disease after transplantation
Results
Of the 18 patients, 16 had undergone cadaveric renal transplantation, and 1 each had undergone liver and heart transplantation. Mean patient age was 62 years (range 47 to 70). Only one of the kidney transplant recipients underwent retransplantation. In the patients who had undergone kidney transplantation, the etiology of end-stage renal disease included hypertension in 5, diabetes mellitus in 2, obstructive uropathy in 1, glomerulonephritis in 2, and was undetermined in 6. Maintenance
Comment
To our knowledge, this is the largest reported series of patients with prostate cancer diagnosed after organ transplantation. Previously published data describe series of 3 or fewer patients.6, 7, 8, 9 These reports describe successful outcome after radical prostatectomy, but the small numbers involved do not permit any meaningful analysis of incidence and outcome in these patients. Moreover, follow-up information is scant for most of these cases.
Data from the National Cancer Data Base for
Conclusions
The incidence of prostate cancer in the post-transplant population has probably been underestimated because most transplant centers have only recently begun routine periodic screening for this disease with PSA and DRE. Prostate cancer is receiving an unprecedented degree of attention in the general male population and justifiably so because it has become the most common male cancer. Therefore, we thought it important to examine the incidence and treatment of prostate cancer in the male
References (13)
- et al.
Radical prostatectomy for localized prostatic carcinoma in the renal transplant patient
J Urol
(1991) - et al.
Prostate cancer after heart transplantation
J Urol
(1995) - et al.
Eliminating the need for bilateral pelvic lymphadenectomy in select patients with prostate cancer
J Urol
(1994) - et al.
Cancer statistics, 1996
CA Cancer J Clin
(1996) Genitourinary malignancies in organ transplant recipients
Semin Urol
(1994)The problem of cancer in organ transplant recipientsan overview
Transpl Sci
(1994)
Cited by (49)
The role of radiotherapy in patients with solid tumours after solid organ transplantation: a systematic review
2021, The Lancet OncologyCitation Excerpt :The reported 1-year overall survival rates ranged from 74% to 100%.27,29,32 We identified 26 publications reporting data on 149 kidney transplant recipients who received radiotherapy (tables 1–3).25,26,41–59 The median interval between transplantation and radiotherapy was 58·5 months (range 6·0–168·0).
Morbidity, perioperative outcomes and complications of robot-assisted radical prostatectomy in kidney transplant patients: A French multicentre study
2020, Urologic Oncology: Seminars and Original InvestigationsCitation Excerpt :Cancer development has become a major problem in KTRs and is currently one of the primary causes of death in this population [4]. Genitourinary malignancies stand for 34% of the nonskin solid cancer in KTR [5]. Prostate cancer (PCa) incidence remains controversial some studies reported a 2 to 5 times higher incidence in KTR [6,7] but other showed a similar or lower incidence than in the general population [2,8].
Radiotherapy and immune suppression: A short review
2020, Bulletin du CancerLow-Dose-Rate and High-Dose-Rate Brachytherapy for Localized Prostate Cancer in ABO-Incompatible Renal Transplant Recipients
2019, Transplantation ProceedingsOutcomes in Organ Transplant Recipients With Prostate Cancer Treated With Radiotherapy
2019, Clinical Genitourinary CancerOur experience in the management of prostate cancer in renal transplant recipients
2018, Actas Urologicas Espanolas