Original contributionPrimary undifferentiated small cell carcinoma of the esophagus☆
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Cited by (87)
Clinicopathological features and outcome of esophageal neuroendocrine tumor: A retrospective multicenter survey by the digestive endoscopy society of Taiwan
2021, Journal of the Formosan Medical AssociationCitation Excerpt :The result was similar using Ki-67 55% as the cut-off level according to the NORDIC study15 (P = 0.09, Table 4). Similar to other GEP-NEC, esophageal NEC has diffusely positive immunostaining for synaptophysin but infrequent positive immunostaining to chromogranin A.4 Consistent with reports from Japan, India and China,5,6,10 our survey found esophageal NECs were commonly small cell type, had a high proportion of mixed NEC with SCC, and middle (43.6%) or upper (10.3%) esophagus sites were not uncommon. On the contrary, studies from the USA3 and Korea9 indicated the major locations of esophageal NET were distal esophagus and gastroesophageal junction, where neuroendocrine cells were mainly distributed.5
A rare rarity: Neuroendocrine tumor of the esophagus
2019, Critical Reviews in Oncology/HematologyCitation Excerpt :Data pertaining to prognostic factors are unclear. While some studies found mixed esophageal NECs tended toward a better outcome than pure esophageal NECs without non-neuroendocrine components (Maru et al. 2008), this was not observed in other studies (Babu Kanakasetty et al., 2016; Takubo et al., 1999). Prognostic factors affecting survival are generally age (Nemoto et al., 2002), the extent of the disease (Ku et al., 2008; Maru et al., 2008), tumor-node-metastasis (TNM) classification (Wang et al., 2013) and local treatment versus local plus systemic treatment (Yun et al., 2007; Chen et al., 2014a; Ding et al., 2013) or chemotherapy (Chen et al., 2014b; Poynton et al., 1997; Lv et al., 2008).
Surgical resection of rare esophageal cancers
2016, Annals of Thoracic SurgeryUpper Gastrointestinal Tract
2022, Handbook of Practical Immunohistochemistry: Frequently Asked QuestionsResection of Combined Esophageal Neuroendocrine Carcinoma Treated with Preoperative Chemotherapy: A Case Report
2022, Japanese Journal of Gastroenterological Surgery
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Supported by a Grant-in-Aid (7-7) for Cancer Research from the Ministry of Health and Welfare and a Grant-in-Aid for Scientific Research (09470264) from the Ministry of Education, Science and Culture of Japan.