Original contributionImmunohistochemical demonstration of MET overexpression in human intrahepatic cholangiocarcinoma and in hepatolithiasis☆
References (39)
- et al.
Overexpression of c-met proto-oncogene product and raised Ki67 index in hepatocellular carcinomas with respect to benign liver conditions
Hepatology
(1995) - et al.
Liver hepatocyte growth factor does not always correlate with hepatocellular proliferation in human liver lesions: Its specific receptor c-met does
Hepatology
(1996) - et al.
Expression of pancreatic enzymes (α-amylase, trypsinogen and lipase) during human liver development and maturation
Gastroenterology
(1995) - et al.
Generation of a truncated hepatocyte growth factor receptor in the endoplasmic reticulum
J Biol Chem
(1994) - et al.
Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed-early response to HGF
J Biol Chem
(1994) - et al.
Hepatocyte growth factor up-regulates met expression in rat fetal hepatocytes in primary culture
Biochem Biophys Res Commun
(1994) - et al.
Hepatotropin mRNA expression in human foetal liver development and in liver regeneration
FEBS Lett
(1990) - et al.
Oncogene expression in cholangiocarcinoma and in normal hepatic development
Hum Pathol
(1989) - et al.
Hepatocyte growth factor and its receptor, the tyrosine kinase encoded by the c-met proto-oncogene
Cell Mol Biol
(1994) - et al.
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
Science
(1991)
The receptor encoded by the human c-met oncogene is expressed in hepatocytes, epithelial cells and solid tumors
Int J Cancer
Coexpression of the c-met proto-oncogene and hepatocyte growth factor in human pancreatic cancer
Cancer Res
Hepatocyte growth factor and met receptor expression in human pancreatic carcinogenesis
Am J Pathol
Expression of the c-met proto-oncogene in human hepatocellular carcinoma
Hepatology
Are hepatolithiasis and cholangiocarcinoma aetiologically related?
Histological features and interphase nucleolar organizer regions in hyperplastic, dysplastic and neoplastic epithelium of intrahepatic bile ducts in hepatolithiasis
Histopathology
Human intrahepatic biliary epithelial cells proliferate in vitro in response to human hepatocyte growth factor
J Clin Invest
Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: Interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro
Hepatology
Induction of invasive growth in a gallbladder cancer cell line by hepatocyte growth factor in vitro
Jpn J Cancer Res
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2020, Surgical OncologyCitation Excerpt :The biological activity of the MET pathway results in increased cell proliferation and motility. In contrast to the normal adult liver parenchyma, which demonstrates no obvious MET expression in any cell types, MET overexpression has been reported in up to 58% of iCCA and 16% of eCCA patients [27,68]. Nakazawa et al. reported significantly higher c-MET overexpression in iCCA compared with any other BTC [69].
The choice for the optimal therapy in advanced biliary tract cancers: Chemotherapy, targeted therapies or immunotherapy
2020, Pharmacology and TherapeuticsTargeting cholangiocarcinoma
2018, Biochimica et Biophysica Acta - Molecular Basis of DiseaseEmerging molecular therapeutic targets for cholangiocarcinoma
2017, Journal of HepatologyCitation Excerpt :Tumors can harness these processes to promote tumor growth and invasion. MET overexpression occurs in iCCA and correlates with the degree of tumor differentiation.31 An integrated molecular analysis identified two distinct biological classes in iCCA, an inflammation class (38% of iCCAs) and a proliferation class (62% of iCCAs).32
Intrahepatic cholangiocarcinoma: Molecular markers for diagnosis and prognosis
2017, Surgical OncologyCitation Excerpt :MET is activated by its ligand HGF, which induces MET kinase catalytic activity and initiates a spectrum of biologic activities collectively known as the invasive growth program. MET overexpression has been associated with increased invasion and poor prognosis in biliary tract cancers, and thus may be helpful as a prognostic biomarker [104,105]. Elevated expression of matrix metalloproteinase (MMP) is known to enhance cancer metastasis.
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Supported by ROI CA39225 to Alphonse E. Sirica from the National Cancer Institute, National Institutes of Health, Bethesda, MD.