Elsevier

Human Pathology

Volume 13, Issue 2, February 1982, Pages 113-122
Human Pathology

Sebaceous carcinomas of the ocular adnexa: A clinicopathologic study of 104 cases, with five-year follow-up dataa,b

https://doi.org/10.1016/S0046-8177(82)80115-9Get rights and content

One hundred four cases of sebaceous carcinoma that arose from ocular adnexa, with at least five years' follow-up information following diagnosis, were studied to extend the authors' previous observations on various prognostic factors in these tumors. Twenty-three patients died from metastatic disease. Although sebaceous carcinomas elsewhere in the skin are rare, this study established that these neoplasms occur much more frequently in the ocular adnexa and have significant morphologic features that identify the more highly lethal carcinomas. The various clinicopathologic features that indicated a bad prognosis were vascular, lymphatic, and orbital invasion; involvement of both upper and lower eyelids; poor differentiation; multicentric origin; duration of symptoms greater than six months; tumor diameter exceeding 10 mm; a highly infiltrative pattern; and pagetoid invasion of the overlying epithelia of the eyelids. In many cases pagetoid change appeared to originate in the underlying sebaceous glands and from there extended to invade the overlying epithelia.

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      Citation Excerpt :

      The aetiology of SC is unknown, but it has been reported following ionizing radiation therapy for cavernous haemangioma, retinoblastoma and barber's itch called folliculitis barbae in a syndromic human disease [13]. Various predictive factors such as vascular and lymphatic invasion, poor differentiation, multicentric origin, duration of symptoms longer than 6 months, tumour diameter exceeding 10 mm and a highly infiltrative pattern have been identified for poor prognosis of the tumour [3]. The management of the tumour is by surgical removal of the localized tumours on the skin and the removal of the regional lymph nodes if metastasis has occurred [6].

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    a

    This investigation was supported in part by research grants EY-02155, EY-07040, and EY-10386 from the National Eye Institute.

    b

    The opinions and assertions contained herein are the private views of the authors and are not to be construcd as official or as reflecting the views of the Department of the Army or the Department of Defense.

    *

    From the Departments of Ophthalmology and Pathology, Georgetown University Medical Center, Washington, DC.

    From the Registry of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC.

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