Original ArticlesValue of Preoperative CA 125 Level in the Management of Uterine Cancer and Prediction of Clinical Outcome☆
Section snippets
Materials and Methods
Preoperative CA 125 levels were available from 210 patients with endometrial cancer who were treated at four centers between January 1985 and December 1993: 174 from the University of Iowa Hospitals and Clinics, and 36 from the University of California at Irvine and affiliated hospitals (Long Beach Memorial Hospital, City of Hope National Medical Center, and University of California at Irvine). All patients at these institutions with endometrial cancer diagnosed during the study period were
Results
The average age of the study patients was 62.7 years, with a range of 27 to 93 years. Characteristics of these patients and their cancers are listed in Table 1. The mean period of follow-up was 3.0 years (range 0–8.5 years). Eighty-six patients underwent a simple hysterectomy for treatment, whereas 124 also underwent bilateral pelvic lymph node dissection with or without para-aortic lymph node sampling. Sixty-seven percent of tumors were classified as adenocarcinoma, 11.4% as papillary serous,
Discussion
Uterine cancer is the most common gynecologic malignancy in women in the United States. Most patients present with early-stage disease; however, about 25% of patients present with stage III or higher disease and will require adjuvant therapy. The most common method of diagnosis for uterine cancer is an office endometrial biopsy or D&C. Thus, before treatment, only a few factors are available on which to base treatment decisions. These factors are patient’s age, histology, and grade of tumor. It
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This project was supported in part by the American Cancer Society Clinical Oncology Fellowship Award (number 95-39-1) to Anil K. Sood, MD.