In situ detection of DNA fragmentation and expression of bcl-2 in human neuroblastoma: Relation to apoptosis and spontaneous regression☆
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Proteomics-based identification of spontaneous regression-associated proteins in neuroblastoma
2011, Journal of Pediatric SurgeryCitation Excerpt :Some researchers believed that neuroblastoma tissue was derived from a malignant transformation of degenerated embryonic tissue; therefore, its spontaneous regression might be, in fact, regression of the embryo. Recently, some groups found morphologic features of apoptosis in stage 4s neuroblastomas, which led to the assumption that apoptosis, which is a representative form of programmed cell death (PCD), might play an important role in the spontaneous regression of neuroblastoma [9,10]. However, others failed to find evidence of a correlation between apoptosis and spontaneous regression [11-13].
Cytotoxic T-lymphocytes secrete soluble factors that induce caspase-mediated apoptosis in glioblastoma cell lines
2010, Journal of NeuroimmunologyDifferential response of neuroblastoma cells to TRAIL is independent of PI3K/AKT
2006, Journal of Pediatric SurgeryNeuroblastoma
2006, Pediatric Surgery: Sixth EditionImbalance of the mitochondrial pro- and anti-apoptotic mediators in neuroblastoma tumours with unfavourable biology
2005, European Journal of CancerCalreticulin expression in neuroblastoma - A novel independent prognostic factor
2005, Annals of OncologyCitation Excerpt :In addition, many normally expressed molecular markers in embryonic neuroblastic cells, such as HNK-1, tyrosine hydroxylase, Trk-A and CD44, are found in NBs, suggesting that NB arises during the developmental stages of the embryonic sympathetic system [3, 4]. Furthermore, expression of apoptosis-related genes has been demonstrated in NB [5], and patients with NB tumors that showed more apoptosis had a better prognosis [6]. These studies suggest that failure of either differentiation or regression by apoptotic death of NB cells is critical for the development of clinical NB.
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Presented at the 28th Annual Meeting of the Pacific Association of Pediatric Surgeons, Huatulco, Oaxaca, Mexico, May 14–18, 1995.