Original ArticleDevelopment and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD
Section snippets
Patients and methods
The study was divided into 4 parts. In the first part, the most relevant endoscopic variables were selected and their reproducibility level was evaluated in an interobserver variation study. For the second part, the development phase, an endoscopic score was derived from the selected endoscopic variables and further simplified (the SES-CD) to obtain a score that was still highly correlated to the CDEIS but was simpler and easier to calculate. In the third part, the validation phase, a set of
Patient characteristics
The clinical characteristics of the patients are described in Table 2 for patients included in the development phase, those of the validation set, and for the entire sample. There was no significant difference in clinical characteristics among the patients by center or between patients in both phases of the study.
Selection of parameters and reproducibility levels
The items included in the SES-CD were the result of a careful review of the GETAID studies with regard to the importance and the reproducibility of the most relevant endoscopic
Discussion
The assessment of mucosal involvement in patients with Crohn's disease in an objective and a reliable way is an important issue for clinicians who care for patients with this disease. Endoscopy is by far the best and the most widely used modality for assessment of the extent and the severity of Crohn's disease in the terminal ileum and the colon; it is markedly superiority to barium contrast radiography.13 Although earlier studies have clearly demonstrated that mucosal healing is not predictive
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Preliminary data of this study were presented as posters at Digestive Diseases Week, May 19-23, 2002, San Francisco, California (Gastroenterology 2002;122:S1376), and Digestive Diseases Week, May 18-21, 2003, Orlando, Florida, and as an oral presentation at United European Gastroenterology Week 2002, October, 2002, Geneva, Switzerland (Gut 2002;51(Suppl III):A56).