Does Resection of Adrenal Metastases From Non-Small Cell Lung Cancer Improve Survival?
Section snippets
Material and Methods
We performed a retrospective review of patients with the diagnosis of NSCLC and a solitary adrenal metastasis who presented to Memorial Sloan Kettering Cancer Center from 1987 to 1993. Eligibility criteria included a resectable primary NSCLC, a solitary adrenal metastasis, good performance status (Eastern Cooperative Oncology Group class 0 or 1), no history of other malignancies, and an otherwise negative metastatic survey. Patients were selected for chemotherapy alone or chemotherapy followed
Results
Fourteen patients treated for an isolated adrenal metastasis were identified. All adrenal metastases in the current series were detected during the workup of the primary lung cancer. The adrenal metastases were verified by histologic review of percutaneous needle biopsy or open biopsy specimens. There was no difference in age, sex, performance status, tumor histology, or size of adrenal metastasis between the two groups (Table 1). There was no significant difference in the locoregional stage of
Comment
More than 170,000 new cases of lung cancer are diagnosed each year; 80% are non-small cell and 20% are small cell lung cancer. Of the NSCLC, 50% are considered unresectable at the time of diagnosis due to the presence of distant metastases. In a review of more than 2,500 patients presenting with metastatic NSCLC, Albain and associates [1]reported 7% had a solitary site of metastasis. In this group, a multivariate analysis revealed that a solitary site of metastasis was a favorable prognostic
References (15)
- et al.
Resection of brain metastasis from non-small-cell lung carcinoma. Results of therapy. Memorial Sloan-Kettering Cancer Center Thoracic Surgical Staff
J Thorac Cardiovasc Surg
(1992) - Albain KS, Crowley JJ, LeBlanc M, Livingston RB. Survival determinants in extensive-stage non-small-cell lung cancer:...
- et al.
A randomized trial of surgery in the treatment of single metastases to the brain
N Engl J Med
(1990) - Read RC, Boop WC, Yoder G, Schaefer R. Management of non-small cell lung carcinoma with solitary brain metastases. J...
- Luketich JD, Martini N, Ginsberg RJ, Rigberg D, Burt ME. Successful treatment of solitary extracranial metastases from...
- Burt ME, Heelan R, Coit D, McCormack PM, Ginsberg RJ. Prospective evaluation of unilateral adrenal metastases in...
- Twomey P, Montgomery C, Clark O. Successful treatment of adrenal metastases from large-cell carcinoma of the lung. JAMA...
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