Scientific paperTreatment of invasive breast carcinoma with ultrasound-guided radiofrequency ablation
Section snippets
Subjects
Subjects were 22 women, aged 60 years or older, with core-biopsy proven invasive breast cancer less than 3 cm in diameter. Tumors had to be visible on ultrasound, at least 1 cm from the skin, mobile from the chest wall and have adequate histology on core biopsy to permit unequivocal identification of invasive disease, tumor grade and assessment of estrogen receptor status. Patients were required to complete a short quality of life form and those with pacemakers or taking anticoagulants were
Results
Among 29 patients approached for the study, 22 consented and were entered into study (Table 1). All patients were successfully treated as outpatients. The age range was 60 to 80 years with a median of 73 years. Most had mammographically detected, nonpalpable tumors <2 cm diameter and no palpable axillary nodes. All had histologically confirmed invasive breast cancer on core needle biopsy (Table 2). A majority had <50% glandular tissue on the mammogram. Three patients (14%) had a previous breast
Comments
Modern imaging technologies and breast screening programs have resulted in the identification of breast cancer at earlier stages and at smaller tumor sizes [13]. This has facilitated the expanded use of breast conservation and reduced the morbidity from systemic therapy [14]. While surgical therapy for breast cancer has evolved from radical mastectomy to lumpectomy, the concept of tumor ablation as a method of definitive local control would be a conceptual shift from traditional extirpation
Acknowledgements
This work was supported by a grant from the Canadian Breast Cancer Foundation, BC/Yukon Chapter.
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