The Journal of Steroid Biochemistry and Molecular Biology
11β-Hydroxysteroid dehydrogenases: Participation in hormone synthesis and tissue-specific responsiveness to glucocorticoidThe human 11β-hydroxysteroid dehydrogenase type II enzyme: Comparisons with other species and localization to the distal nephron
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Cited by (31)
Recent advances in the study of 11β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2)Inhibitors
2017, Environmental Toxicology and PharmacologyCitation Excerpt :For fetus, cortisol has been demonstrated to check fetal development, cause cardiovascular, metabolic, neuropsychiatric disorders (Parry et al., 1976; Seckl, 2004), even teratogenesis (Benediktsson et al., 1993) and may also predispose individuals to hypertension in adulthood (Benediktsson et al., 1993). 11β-HSD2 is localized in the syncytiotrophoblast of the placental (Krozowski et al., 1995) and may prevent this dysgenesis by eliminating active GCs on the maternal side of the placenta to prevent them from reaching the fetal circulation (Kajantie et al., 2003), thus preserving the low GCs fetal environment (Brown et al., 1993). So 11β-HSD2 inhibition by environmental chemicals would cause harmful effects on placental function and fetal development (Reinisch et al., 1978).
In utero perfluorooctane sulfonate exposure causes low body weights of fetal rats: A mechanism study
2016, PlacentaCitation Excerpt :HSD11B2 has been found in non-mineralocorticoid receptor target tissues such as the placenta. In the placenta, HSD11B2 is localized in the syncytiotrophoblast, which is the site of maternal–fetal exchange [26]. The placental HSD11B2 plays a critical role in the fetal maturation.
Endocrine disruptors and other inhibitors of 11β-hydroxysteroid dehydrogenase 1 and 2: Tissue-specific consequences of enzyme inhibition
2016, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :However, the best documented mechanism of obesogen action is PPARγ activation, which is a key regulator of adipogenesis [115]. Renal 11βHSD2 is highly expressed in distal tubules and collecting ducts as well as MRs [117]. Since MR is a non-selective receptor, it can bind not only mineralocorticoid aldosterone but also active glucocorticoids (cortisol in primates and corticosterone in rodents).
Steroid hormones in prediction of normal pressure hydrocephalus
2015, Journal of Steroid Biochemistry and Molecular BiologyPost-translational modifications of the mineralocorticoid receptor: How to dress the receptor according to the circumstances?
2014, Journal of Steroid Biochemistry and Molecular Biology