Paper
Symptoms and signs in metastatic spinal cord compression: a study of progression from first symptom until diagnosis in 153 patients

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Abstract

The symptoms in metastatic compression of the spinal cord or cauda equine are described after a systematic recording of the sequence of symptoms in 153 patients. Radicular pain was predominant in patients with metastases located in the lumbar area, while the severity of motor symptoms was positively correlated with thoracic metastases. The most common initial symptom was radicular poin, followed, with decreasing frequency, by motor weakness, sensory complaints and bladder dysfunction. The progression of motor weakness influenced the probability of establishing the diagnosis of spinal cord compression by stepwise marked increased probability when patients lost gait function or progressed into total paralysis.

References (15)

  • P Latini et al.

    Role of radiotherapy in metastatic spinal cord compression: preliminary results from a prospective trial

    Radiother Oncol

    (1989)
  • CA Elsberg

    Extradural spinal tumors—primary, secondary metastatic

    Surg Gynecol Obstet

    (1928)
  • BW Ongerboer de Visser et al.

    Radiation treatment of epidural metastases with compression of the spinal cord or cauda equina: a prospective study of 50 patients

    Ned Tijdschr Geneeskd

    (1983)
  • J Whittaker

    Graphical Models in Applied Multivariate Statistics

    (1976)
  • S Kreiner

    Analysis of multidimensional contingency tables by exact conditionel tests: techniques and strategies

    Scand Stat

    (1976)
  • A Agresti

    Analysis of Ordinal Categorical Data

    (1984)
  • DR Cox et al.

    Analysis of Survival Data

    (1984)
There are more references available in the full text version of this article.

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