PaperGenistein inhibits tumour cell growth in vitro but enhances mitochondrial reduction of tetrazolium salts: A further pitfall in the use of the MTT assay for evaluating cell growth and survival
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2020, Journal of Controlled ReleaseCitation Excerpt :Pagliacci et al. observed that genistein inhibited cancer cells growth; however, during the MTT assay, genistein increased the formazan production which causing false negative results. They indicated that genistein increased formazan formation in G2/M arrested tumor cells owing to an enhancement of mitochondrial activity [28]. On the other hand, MTT's lipophilicity can also be problematic.