Original ContributionInteractions of 1,10-phenanthroline and its copper complex with Ehrlich cells
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Cited by (23)
TiO<inf>4</inf>N<inf>2</inf> complexes formed with 1,10-phenanthroline ligands containing a donor-acceptor hydrogen bond site: Synthesis, cytotoxicity and docking experiments
2022, Inorganica Chimica ActaCitation Excerpt :The X-ray diffraction data for [Ti(1)2(A)], [Ti(1)2(F)] were collected at and 173 K on a Bruker SMART CCD diffractometer with MoKα radiation (λ = 0.71073 Å). The diffraction data were corrected for absorption using the SADABS program [36]. The structures were solved using SHELXS97 [37] and refined by full matrix least-squares on F2 using SHELXL-2014 [38] in the anisotropic approximation for all non-hydrogen atoms.
In vitro activity of N-phenyl-1,10-phenanthroline-2-amines against tachyzoites and bradyzoites of Toxoplasma gondii
2021, Bioorganic and Medicinal ChemistryCitation Excerpt :Apart from sequestering metals, which could affect a wide range of proteins, the resulting 1,10-Phen-metal complexes are highly active and play an important role in the activity of this compound.53,54 Phen derivatives, as a free ligand or in metal complexes, have strong hydrophobicity, planarity and rigidity, enabling them to interact with DNA through intercalation or as groove binding agents, as cleaving agents or may induce oxidative modifications.55–57 Treatment of cancer cells with 1,10-phenanthroline-5,6-dione and its copper derivatives was shown to inhibit DNA synthesis in neoplastic human cell lines.58
The cytotoxicity of some phenanthroline-based antimicrobial copper(II) and ruthenium(II) complexes
2018, Journal of Inorganic BiochemistryCitation Excerpt :Although cytotoxicity is a key consideration of compounds with potential antibiotic or disinfectant application, low genotoxicity is desired. Bis-1,10-phenanthroline copper(II) complexes have been observed to undergo reduction to copper(I) and induce single-strand DNA breaks in mouse abdominal tumour cells [15]. The DNA binding capacity of antimicrobial ternary complexes of phen and dach ligands noted in previous studies may contribute to their target cell mode of action, potentially via speciation to bis-phen complexes, however may also induce mutagenesis in human cells [5].
Radical-induced DNA damage by cytotoxic square-planar copper(II) complexes incorporating o-phthalate and 1,10-phenanthroline or 2,2′-dipyridyl
2012, Free Radical Biology and MedicineCitation Excerpt :As a result of the link between copper(I)- and copper(II)-containing molecules and the generation and detoxification of free radicals, there has been a sustained interest in the rational design and therapeutic evaluation of small molecules containing redox-active metal cations [19–27]. In particular, the design of copper(II) anticancer chemotherapeutics capable of targeting DNA represents both an attractive and a multifaceted prospect [28–39]. In comparison to platinum(II) chemotherapeutic agents (Fig. 1), whose coordination chemistry is dominated through the trans effect, and with DNA toxicity being mediated directly through Pt(II)–guanine substitution kinetics [40–42], copper(II) compounds are structurally influenced through the Jahn–Teller effect and induce DNA toxicity both indirectly through free radical modification of 2-deoxyribose or base moieties [43] and directly through Cu(II)–guanine/adenine binding [44,45].
Mechanism of the synergistic cytotoxicity between pentachlorophenol and copper-1,10-phenanthroline complex: The formation of a lipophilic ternary complex
2000, Chemico-Biological InteractionsCitation Excerpt :It has been shown that Cu(II)(OP)2 complex could non-covalently bind to DNA [14–16]. In the presence of biological reducing agents, both single and double strand breaks could be produced through a site-specific mechanism, both in vitro [14–16] and in vivo systems [17–21]. The ineffective protection of SOD and catalase by their catalytic functions, and the ineffectiveness of DMSO as a hydroxyl radical scavenger, also point to the site-specific nature of cellular damage by the PCP/Cu(II)(OP)2 system.
Inhibition of hydroperoxide-induced DNA single-strand breakage by 1,10- phenanthroline in HL-60 cells: Implications for iron speciation
1996, Archives of Biochemistry and Biophysics