Genomic organization, chromosomal localization, and independent expression of human cyclin D genes
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2021, Cancer Treatment and Research CommunicationsCitation Excerpt :If favorable environmental conditions are available, mitogens trigger intracellular signaling pathways, which activate promoters of cyclins D, and through the mediation of retinoblastoma (Rb) phosphorylation, they lead to the progression of the cell cycle [2]. In mammalian cells cyclins D are encoded by the three separate genes on three distinct chromosomes (CCND1: 11q13.3, CCND2: 12p13.32, CCND3: 6p21.1) [3], and they show different tissue and disease specificity. Usually, one dominant cyclin drives the cell cycle progression exclusively in a particular cell type [4] and may be indispensable for the appropriate tissue development [5].
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Sequence data from this article have been deposited with the Gen-Bank Data Library under Accession Nos. M88080, M88081, M88082, M88083, M88084, M88085, M88086, M88087, M86182, M86183.