Original contribution
Tolerance of normal tissue to therapeutic irradiation

https://doi.org/10.1016/0360-3016(91)90171-YGet rights and content

Abstract

The importance of knowledge on tolerance of normal tissue organs to irradiation by radiation oncologists cannot be overemphasized. Unfortunately, current knowledge is less than adequate. With the increasing use of 3-D treatment planning and dose delivery, this issue, particularly volumetric information, will become even more critical. As a part of the NCI contract N01 CM-47316, a task force, chaired by the primary author, was formed and an extensive literature search was carried out to address this issue. In this manuscript we present the updated information on tolerance of normal tissues of concern in the protocols of this contract, based on available data, with a special emphasis on partial volume effects. Due to a lack of precise and comprehensive data base, opinions and experience of the clinicians from four universities involved in the contract have also been contributory. Obviously, this is not and cannot be a comprehensive work, which is beyond the scope of this contract.

References (197)

  • F. Ellis

    Dose, time and fractionation: A clinical hypothesis

    Clin. Radiol.

    (1969)
  • W.E. Enker et al.

    Defining the needs for adjuvant therapy of rectal and colonic cancer

    Surg. Clin. North Am.

    (1981)
  • R.G. Evans

    Radiobiological considerations in magna-field irradiation

    Int. J. Radiat. Oncol. Biol. Phys.

    (1983)
  • C.J.H. Fryer et al.

    Radiation pneumonitis: Experience following a large single dose of radiation

    Int. J. Radiat. Oncol. Biol. Phys.

    (1978)
  • P.M.S. Gillam et al.

    Chronic bronchitis and radiotherapy of the lung

    Lancet

    (1964)
  • E. Haddad et al.

    Liver complications in lymphomas treated with a combination of chemotherapy and radiotherapy: Preliminary results

    Int. J. Radiat. Oncol. Biol. Phys.

    (1983)
  • A.R. Harwood et al.

    Radiotherapy of early glottic cancer

    Int. J. Radiat. Oncol. Biol. Phys.

    (1979)
  • R.M. Henkelman et al.

    How important is breathing in radiation therapy of the thorax?

    Int. J. Radiat. Oncol. Biol. Phys.

    (1982)
  • M.J. Ikaheimo et al.

    Early cardiac changes related to radiation therapy

    Am. J. Cardiol.

    (1985)
  • S.-W. Jao et al.

    Surgical treatment of radiation injuries of the colon and rectum

    Am. J. Surg.

    (1986)
  • T.J. Keane et al.

    Idiopathic interstitial pneumonia following bone marrow transplantation: The relationship with total body irradiation

    Int. J. Radiat. Oncol. Biol. Phys.

    (1981)
  • T.H. Kim et al.

    Acute transient radiation hepatitis following whole liver irradiation

    Clin. Radiol.

    (1976)
  • T.J. Kim et al.

    Unilateral radiation nephropathy-the long term significance

    Int. J. Radiat. Oncol. Biol. Phys.

    (1984)
  • T.J. Kinsella et al.

    Adriamycin cardiotoxicity in stage IV breast cancer: Possible enhancement with prior left chest radiation therapy

    Int. J. Radiat. Oncol. Biol. Phys.

    (1979)
  • L.B. Kline et al.

    Radiation optic neuropathy

    Ophthalmology

    (1985)
  • A. Kuten et al.

    Oral side effects of head and neck irradiation: Correlation between clinical manifes tations and laboratory data

    Int. J. Radiat. Oncol. Biol. Phys.

    (1986)
  • H.I. Libshitz et al.

    Complications of radiation therapy: The thorax

    Semin. Roentgenol.

    (1974)
  • P.F. Anseline et al.

    Radiation injury of the rectum: Evaluation of surgical treatment

    Ann. Surg.

    (1981)
  • M.M. Applefield et al.

    The late appearance of chronic pericardial disease in patients treated by radiotherapy for Hodgkin's disease

    Ann. Intern. Med.

    (1981)
  • S.A. Aristizabal et al.

    Endocrine factors influencing radiation injury to central nervous tissue

    Int. J. Radiat. Oncol. Biol. Phys.

    (1989)
  • E.M. Ashenhurst et al.

    Lumbo-sacral radiculopathy induced by radiation

    J. Can. Sci. Neurol.

    (1977)
  • H.L. Atkins et al.

    Time-dose considerations in radiation myelopathy

    Acta Radiol. Ther. Phys. Biol.

    (1966)
  • J.M. Bedwinek et al.

    Osteonecrosis in patients treated with definitive radiotherapy for squamous cell carcinomas of the oral cavity and naso- and oropharynx

    Radiology

    (1976)
  • D.E. Bennett et al.

    Bilateral radiation pneumonitis, a complication of the radiotherapy of bronchogenic carcinoma: (Report and analysis of seven cases with autopsy)

    Cancer

    (1969)
  • B.M. Birkhead et al.

    Assessment of renal function following irradiation of the intact spleen for Hodgkin's disease

    Radiology

    (1979)
  • G. Boden

    Radiation myelitis of the cervical spinal cord

    Br. J. Radiol.

    (1948)
  • S.J. Borsanyi et al.

    Ionizing radiation and the ear

    JAMA

    (1962)
  • J.M. Brown et al.

    Mural thrombosis of the heart induced by radiation. (A study in 180 mice—Stanford Medical Center)

    Arch. Pathol.

    (1973)
  • P.C. Burger et al.

    The morphological effects of radiation administered therapeutically for intracranial gliomas

    Cancer

    (1979)
  • R. Byhardt et al.

    Dose and treatment factors in radiation related pericardial effusion with the mantle technique for Hodgkin's disease

    Cancer

    (1975)
  • R.S. Carmel et al.

    Mantle irradiation of Hodgkin's disease

    Cancer

    (1976)
  • R.A. Castellino et al.

    Latent radiation injury of lungs or heart activated by steroid withdrawal

    Ann. Intern. Med.

    (1974)
  • V.T. Cheng et al.

    Osteoradionecrosis of the mandible resulting from external megavoltage therapy

    Therapeut. Radiol.

    (1974)
  • L. Cohen

    Biophysical models in radiation oncology

    (1983)
  • K.E. Cohn et al.

    Heart disease following radiation

    Medicine

    (1967)
  • J.T. Curnes et al.

    Magnetic resonance imaging of radiation injury to the brain

    Am. J. Roentgenol.

    (1986)
  • A. Dias

    Effects on the hearing of patients treated by irradiation in the head and neck area

    J. Laryngol.

    (1966)
  • B.G. Douglas et al.

    The effect of multiple small doses of x-rays on skin reactions in the mouse and a basic interpretation

    Radiat. Res.

    (1976)
  • J.R. Duttenhaver et al.

    Protons or megavoltage X-rays as boost therapy for patients irradiated for localized prostatic carcinoma. An early Phase I/II comparison

    Cancer

    (1983)
  • J. Einhorn et al.

    Hypothyroidism after external irradiation to the thyroid region

    Radiology

    (1967)
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    Supported in part by NCI Contracts N01 CM-47316, N01 CM-47695, N01 CM-47696, N01 CM-47697, Y01 CM-20110.

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