Effect of tamoxifen on intraperitoneal N-nitroso-N-methylurea induced tumors
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2019, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :In this sense, it is worth noting that CPF effects on breast cancer disease reported in this work can be present even in the commonly considered sub-toxic exposures. Previous studies performed in NMU-induced mammary tumorigenesis demonstrated that NMU-induced tumors are strongly regulated by hormones such as E2 and prolactin, as well as by growth factors [22,30,31], making it a suitable experimental model to evaluate the action of putative EDs such as CPF. In this work, we reported an increment in tumor incidence in animals exposed to this pesticide.
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2018, Journal of EthnopharmacologyCitation Excerpt :Group 3 (Vehicle control) animals received sesame oil as per the body weight. Group 4 served as standard control and received Tamoxifen (1 mg/kg b.w; s.c) (Martin et al., 1996). Group 5–7 were test groups which received MEBM − 100 mg/kg; 200 mg/kg and 400 mg/kg p.o respectively.
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2017, International Journal of Biological MacromoleculesCitation Excerpt :This effect of TMX is dependent on concentration. Nanomole concentrations of TMX only cause growth arrest whereas at micromole concentrations, the drug induces cell death [7,31,38]. By regulating estrogen receptors, tamoxifen forestalls tumor growth in mammary tissue.
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