Research sectionEffects of caffeine on glandular stomach carcinogenesis induced in rats by N-methyl-N′-nitro-N-nitrosoguanidine and sodium chloride
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Cited by (35)
Drinking for protection? Epidemiological and experimental evidence on the beneficial effects of coffee or major coffee compounds against gastrointestinal and liver carcinogenesis
2019, Food Research InternationalCitation Excerpt :As in animal studies on oral and esophageal carcinogenesis, there are few animal studies on the effects of caffeine or chlorogenic acid on gastric carcinogenesis (Table 4). Nishikawa et al. (1995) observed that caffeine treatment reduced the incidence of pyloric AC and lipid hydroperoxide levels in the gastric mucosa of male Wistar rats submitted to MNNG and NaCl-induced carcinogenesis. Ultimately, the chlorogenic acid treatment led to a reduction of the incidence of MNU-induced adenomatous hyperplasia and AC, as well as to a decrease in proliferating cell nuclear antigen (PCNA) labeling indexes in non-neoplastic glandular areas (Shimizu et al., 1999).
Evaluation of anticancer effects and enhanced doxorubicin cytotoxicity of xanthine derivatives using canine hemangiosarcoma cell lines
2013, Research in Veterinary ScienceCitation Excerpt :Caffeine and theophylline, a methylxanthine derivative (Fig. 1), increase cAMP by inhibiting phosphodiesterase activity and are well known to have diuretic, cardiac, and central nervous system stimulatory effects. In addition, recent studies have revealed in cultured rat and human cells that caffeine inhibits human tumor colony formation in vitro (Tomita and Tsuchiya, 1989) and the development of tumors in vivo induced by various carcinogens in numerous organs including skin (Huang et al., 1997), lung (Lu et al., 2006), stomach (Nishikawa et al., 1995) and liver (Hosaka et al., 1984). Caffeine is an inhibitor of ataxia telangiectasia mutated (ATM) and ATM-Rad3-related (ATR) kinases, which are master regulators of DNA damage-induced cell cycle checkpoints (Zhou et al., 2000).
Mechanisms of chronic disease causation by nutritional factors and tobacco products and their prevention by tea polyphenols
2002, Food and Chemical ToxicologyHepatocarcinogenesis inhibition by caffeine in ACI rats treated with 2-acetylaminofluorene
2001, Food and Chemical Toxicology