New productsSynthesis of gem-bisphosphonic methotrexate conjugates and their biological response towards Walker's osteosarcoma
References (11)
- et al.
Eur J Med Chem
(1992) - et al.
Tetrahedron Lett
(1977) - et al.
Tetrahedron Lett
(1967) - et al.
J Am Chem Soc
(1953) - et al.
J Med Chem
(1982)
Cited by (44)
Catalytic N-diphosphonomethylation of amino alkanols and bisamino alkanes using tris(trimethylsilyl) phosphite as a convenient synthon
2022, Journal of Organometallic ChemistryCitation Excerpt :So methylenebisphosphonic acids with aromatic moieties may be perspective inhibitors of HIV-1 [20], and new quinolyl substituted aminomethylenebisphosphonic acids which recently obtained by us [21] are the closest structural analogues of chloroquine which is currently a possible chemotherapeutic agent against the virus COVID-19 [22–24]. The various aminomethylenebisphosphonic acids have attached attention in the capacity of excellent chelators for heavy metal detoxification [25–28] and promising radiopharmaceuticals [29–32]. Thus the search for convenient routes to new types of functionalized methylenebisphosphonic acids with hydroxyl and amino groups is an area of active study.
Synthesis of new functionalized aryl and pyridyl aminomethylenebisphosphonic acids and their derivatives via silicon-assisted methodology
2020, Journal of Organometallic ChemistryNew Amino-Bisphosphonate Building Blocks in the Synthesis of Bisphosphonic Derivatives Based on Lead Compounds
2015, Phosphorus, Sulfur and Silicon and the Related Elements(2-Formyl-1-phenylcyclopropyl)phosphonates as building blocks for (2-aminomethyl-cyclopropyl)phosphonates
2011, TetrahedronCitation Excerpt :For the purpose of the present study, we considered the diastereomeric (2-formylcyclopropyl)phosphonates (Z)- and (E)-6 as suitable building blocks. It is well known that inter- and intramolecular cyclopropanation can be achieved by photochemically11 or transition-metal12 induced carbene transfer from α-diazophosphonates to sufficiently electron-rich olefinic bonds. With acroleins as olefinic substrates, however, these strategies are likely to fail.13