Original paperFractionated stereotactic radiotherapy with the Leksell Gamma Knife: feasibility study
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Cited by (37)
Cerebral metastases
2022, Progress in Brain ResearchRadiobiology
2022, Progress in Brain ResearchCitation Excerpt :Before 2010 there were very few papers concerning fractionation of Gamma Knife treatments. These papers were mostly concerned either with the feasibility of fractionation (Novotny et al., 1995; Simonova et al., 1995), or glioma treatment (Regine et al., 2000a,b; Simonova et al., 2005). In the past 10 years there have been more than 40 papers about fractionation for a wide variety of Gamma Knife indications.
Gamma Knife radiosurgery: Scenarios and support for re-irradiation
2019, Physica MedicaCitation Excerpt :However in settings where patients may be re-irradiated multiple times in close succession, placing and removing frames may be impractical. There have been several attempts in the past to treat patients with SRS over multiple days, including by leaving them in stereotactic frames for multiple days and treating one fraction each day [56], and devising frames that can be manually removed and replaced on a fixed set of pins [57]. A variety of relocatable frame systems have been developed with a range of acceptance in clinical practice including thermoplastic masks [58], dental-fixation based frames [59,60], combination techniques [61], and relocatable frames with auxiliary monitoring via optical tracking [62] or vacuum monitoring [63].
Five-fraction Gamma Knife radiosurgery using the Extend relocatable system for benign neoplasms close to optic pathways
2015, Practical Radiation OncologyInitial experience with the eXtend System: A relocatable frame system for multiple-session Gamma Knife radiosurgery
2011, World NeurosurgeryCitation Excerpt :Multiple serial sessions of single-fraction radiosurgery are also employed for patients with brain metastases, where new lesions not seen at the time of treatment are seen on follow-up scans. In the past, radiosurgery delivered in more than one session with the Gamma Knife required either a prolonged period of frame application (23) (sometimes used in cases where all lesions could not be reached in a single treatment session) or repeated application of the frame (used in cases where new lesions were found on serial imaging follow-up). For patients with intracranial and systemic disease, these prolonged or repeated frame applications can have a negative effect on the overall quality of life.
Fractionated Stereotactic Radiotherapy as Reirradiation for Locally Recurrent Head and Neck Cancer
2009, International Journal of Radiation Oncology Biology PhysicsCitation Excerpt :However, complications have also been observed in some patients after treatment (12–15). Decreasing the daily dose and increasing the number of radiation treatments while maintaining the precision of radiosurgery may be a desirable option to reduce the level of brain and cranial nerve damage in certain recurrent tumors involving these sensitive tissues in the setting of a previously irradiated field (16). This is the concept of fractionated stereotactic radiation therapy (FSRT).