Age- and gender-related heterogeneity of cancer chromosome aberrations☆
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Sex modulation of the occurrence of jak2 v617f mutation in patients with splanchnic venous thrombosis
2011, Thrombosis ResearchCitation Excerpt :A possible explanation for the higher prevalence of the JAK2 V617F mutation in women with SVT is that sex-related factors contribute to mutation development, conceivably via the 46/1 haplotype. The development of chromosomal aberrations has been shown to be influenced by constitutional as well as exogenous factors, such as age, sex, occupational and iatrogenic exposure [22–25]. Actually, del(5q) and trisomy 8 were more common among women with myelodysplastic syndromes [22,23,25].
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2010, Principles of Gender-Specific MedicineAcute myeloid leukemia with the 8q22;21q22 translocation: Secondary mutational events and alternative t(8;21) transcripts
2007, BloodCitation Excerpt :As shown in Table 1, 35% of female t(8;21) AML patients are missing one X chromosome and 56% of male t(8;21) AML patients lack the Y chromosome. Although loss of the sex chromosomes is a natural phenomenon associated with aging, the loss of sex chromosomes tends to occur at a significantly younger age and at a much higher frequency in patients with t(8;21) AML than in the general population.50 Furthermore, sex chromosome loss in other types of AML occurs in less than 5% of patients.31,50
Aleukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy
2007, BloodCitation Excerpt :Given that t(8;21) patients express an AML1-ETO isoform with a C-terminal deletion, it is important to understand how this protein contributes to leukemia development. A feature of t(8;21) leukemia is the loss of one sex chromosome in approximately half of all patients that occurs at a much higher frequency compared with AML patients with other chromosomal translocations.14–21 Autosomal changes, including trisomy 8, trisomy 4, and deletion of chromosome 7, have also been detected in approximately 13% to 16% of t(8;21) patients and in 2 t(8;21) patient–derived cell lines at the time of establishment.18,21–24
Gender-Specific Aspects of Pediatric Hematology and Oncology
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This study was supported by grants from the Swedish Cancer Society, The Swedish Work Environment Fund, the Children Cancer Fund of Sweden, and the Medical Faculty of Lund University.