Recurrent breakpoints at 9q31 and 22q12.2 in extraskeletal myxoid chondrosarcoma

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Abstract

A cytogenetic study of extraskeletal myxoid chrondrosarcoma cells revealed a complex t(9;22;15)(q31;q12.2;q25) as a primary chromosome change. A reciprocal translocation involving identical breakpoints on chromosomes #9 and #22 in this tumor has been reported in the literature. We suggest that the breakpoints 9q31 and 22.q12.2 are associated with extraskeletal myxoid chondrosarcoma, a comparatively rare tumor of adulthood.

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Supported in part by Grants CA-14555 and CA-41183 from the National Cancer Institute.

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Dr. Turc-Carel is a Fellow of the Association pour la Recherche sur le Cancer.

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C. T-C., P. D. C., and A. A. S. are presently at The Cancer Center, Southwest Biomedical Research Institute, Scottsdale, AZ.

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