Preclinical toxicology studies with azithromycin: genetic toxicology evaluation
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2019, Respiratory MedicineEffect of natamycin on cytochrome P450 enzymes in rats
2013, Food and Chemical ToxicologyCitation Excerpt :There are many contradictory results on the genotoxicity of macrolides. Some reports suggest that macrolides cause a genotoxic effect when using various test systems (Mitchell et al., 1980; Ila and Topaktas, 1999) but others show that some of the macrolides did not induce gene mutation (Sono et al., 1989; Amacher et al., 1993). Natamycin was found to be a non-mutagenic in Salmonella/mammalian microsome mutation assay in S. typhimurium strains, in a mouse lymphoma mutation assay, in chromosome aberration assay with Chinese hamster ovary (CHO) cells and it is not effective on the reproductive performance in rats (EMEA, 1998).
Micronucleus frequency in women with genital Chlamydia Trachomatis infection before and after therapy
2006, Mutation Research - Genetic Toxicology and Environmental MutagenesisBacterial, Fungal, and Parasitic Disease
2004, Medical Complications During PregnancyThe L5178Y/tk(+/-) mouse lymphoma specific gene and chromosomal mutations assay: A phase III report of the U.S. environmental protection agency Gene-Tox program
1997, Mutation Research - Genetic Toxicology and Environmental MutagenesisAzithromycin: the first of the tissue-selective azalides
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