Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

doi:10.1016/0092-8674(90)90601-A

Cell

Volume 60, Issue 3, 9 February 1990, Pages 509-520

https://doi.org/10.1016/0092-8674(90)90601-A Get rights and content

Abstract

We have isolated a series of genomic and cDNA clones mapping within the boundaries of constitutional and tumor deletions that define the Wilms' tumor locus on human chromsome 11 (band p13). The transcription unit corresponding to these clones spans approximately 50 kb and encodes an mRNA approximately 3 kb long. This mRNA is expressed in a limited range of cell types, predominantly in the kidney and a subset of hematopoietic cells. The polypeptide encoded by this locus has a number of features suggesting a potential role in transcriptional regulation. These include the presence of four zinc finger domains and a region rich in proline and glutamine. The amino acid sequence of the predicted polypeptide shows significant homology to two growth regulated mammalian polypeptides, EGR1 and EGR2. The genetic localization of this gene, its tissue-specific expression, and the function predicted from its sequence lead us to suggest that it represents the 11p13 Wilms' tumor gene.

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Cell

ArticleIsolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

Abstract

Cell

FEBS Lett.

Cell

Cell

Genomics

Meth. Enzymol.

Cell

Biochem. Biophys. Res. Commun.

Genomics

Hum. Pathol.

Cell

Hum. Genet.

Cell

Hum. Genet.

Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA

Eur. J. Biochem.

CpG-rich islands and the function of DNA methylation

Nature

The nephroblastomatosis complex and its relationship to Wilms' tumor-a clinicopathological treatise

Perspect. Pediatr. Pathol.

Second malignant neoplasms in survivors of Wilms' tumor: a report from the National Wilms' Tumor Study

J. Natl. Cancer Inst.

Chromosome 11 probes identified with a catalase oligonucleotide

Am. J. Hum. Genet.

Characterization of a panel of somatic cell hybrids for subregional mapping along 11p and within band 11p13

Cytogenet. Cell Genet.

Two anonymous DNA segments distinguish the Wilms' tumor and aniridia loci

Science

EXAFS study of the zinc-binding sites in the protein transcription factor IIIa

Nature

Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours

Nature

Aniridia-Wilms' tumor association: evidence for specific deletion of 11p13

Cytogenet. Cell Genet.

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

Nature

Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein

Structural evidence for the authenticity of the human retinoblastoma susceptibility gene

Science

Homeo boxes in the study of development

Science

A deletion map of the WAGR region of chromosome 11

Am. J. Hum. Genet.

Cloning of breakpoints of a chromosome translocation identifies the AN2 locus

Science

The fine structure and evolution of the eleventh human chromosome

The β-subunit of follicle-stimulating hormone is deleted in patients with aniridia and Wilms' tumour, allowing a further definition of the WAGR locus

Nature

A fine structure map of human chromosome 11p: analysis of the J1 series hybrids

Somatic Cell Mol. Genet.

Retroviral Cys-Xaa2-Cys-Xaa2-Cys peptide binds metal ions: spectroscopic studies and a proposed three-dimensional structure

Familial predisposition to Wilms' tumour does not map to the short arm of chromosome 11

Nature

Isolation and localization of DNA segments from specific human chromosomes

Abnormalities in structure and expression of the human retinoblastoma gene in SCLC

Science

Point mutational inactivation of the retinoblastoma antioncogene

Science

Suppression of the neoplastic phenotype by replacement of the retinoblastoma gene product in human cancer cells

Science

Lack of linkage of familial Wilms' tumour to chromosomal band 11p13

Nature

Article
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

Retroviral Cys-Xaa₂-Cys-Xaa₂-Cys peptide binds metal ions: spectroscopic studies and a proposed three-dimensional structure