Cell
ArticleOverexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells
References (51)
- et al.
SV40 T antigen induction and transformation in human fibroblast cell strains
Virology
(1968) - et al.
Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185
Cell
(1986) - et al.
MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF
Biochem. Biophys. Res. Commun.
(1985) - et al.
A new technique for the assay of infectivity of human adenovirus 5 DNA
Virology
(1973) - et al.
Resolution of high and low affinity epidermal growth factor receptors
Inhibition of high affinity component by low temperature, cycloheximide, and phorbol esters
J. Biol. Chem.
(1982) - et al.
Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbB protein
Cell
(1985) - et al.
Reconstitution of human epidermal growth factor receptors and its deletion mutants in cultured hamster cells
J. Biol. Chem.
(1986) - et al.
Agar suspension culture for the selective assay of cells transformed by polyoma virus
Virology
(1964) - et al.
c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor
Cell
(1985) - et al.
Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas
Cell
(1982)
The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1
Cell
Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells
Cell
Identification of epidermal growth factor receptors in a hyperproducing human epidermoid carcinoma cell line
J. Biol. Chem.
The erbB gene of avian erythroblastosis virus is a member of the src gene family
Cell
Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo
Lancet
Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization
In Vitro
Antibodies to the epidermal growth factor receptor block the biological activities of sarcoma growth factor
Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus
Nature
Sequencing the erbA gene of avian erythroblastosis virus reveals a new type of oncogene
Science
Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors
Cancer Res.
erbB-2 is a potent oncogene when overexpressed in NIH 3T3 cells
Science
Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor
Science
Close similarity of epidermal growth factor receptor and v-erbB oncogene protein sequences
Nature
Nerve growth factor receptors on human melanoma cells in culture
The human transforming growth factor type alpha coding sequence is not a direct-acting oncogene when overexpressed in NIH 3T3 cells
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