Cell
ArticleButyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cells
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2020, Journal of Controlled ReleaseEpigenetic mechanisms underlying the therapeutic effects of HDAC inhibitors in chronic myeloid leukemia
2020, Biochemical PharmacologyCitation Excerpt :Within the class of short-chain fatty acids, the two most characterized HDACis are sodium 4-phenylbutyrate and valproic acid [37]. The first is derived from sodium butyrate, a prototype compound of the “short-chain fatty acid” family initially reported to induce differentiation in cultured erythroleukemic cells [76] and whose short half-life limits its therapeutic application [1]. Sodium 4-phenylbutyrate shows selective toxicity for leukemia cells against healthy blood cells [77] and underwent a phase II trial for the treatment of pediatric brain tumors (www.clinicaltrials.gov).
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2019, Journal of Pharmaceutical and Biomedical AnalysisManipulating macrophage polarization and function using classical HDAC inhibitors: Implications for autoimmunity and inflammation
2018, Critical Reviews in Oncology/HematologyCitation Excerpt :It is interested to note that, inflammatory stimuli enhanced the sensitivity of macrophages to HDAC inhibitors-inducing apoptosis (Tsolmongyn et al., 2013). Therefore, these data collectively indicate that therapeutic administration of HDAC inhibitors suppresses mature monocyte and macrophage differentiation and functions and also induces their apoptosis at inflammation sites (Abe, 2012; Chateauvieux et al., 2011; Choo et al., 2010; Dragunow et al., 2006; Falkenberg and Johnstone, 2014; Gibbons et al., 2011; Grabiec et al., 2012, 2010; Joosten et al., 2011; Laribee and Klemsz, 2001; Leder and Leder, 1975; Lohman et al., 2016; Nasu et al., 2008; Shakespear et al., 2011; Shao et al., 2004; Shein et al., 2009; Shi et al., 2012; Sweet et al., 2012; Toussirot et al., 2013, 2010b; Tsolmongyn et al., 2013; Woan et al., 2012; Zini et al., 2012). Therefore, inducing the apoptosis of pro-inflammatory macrophages and other inflammatory cells at sites of inflammation by HDAC inhibitors may contribute to the therapeutic benefits of these small molecules as anti-inflammatory agents (Fig. 2).
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2018, Pharmacological ResearchCitation Excerpt :Notably, it is also present in cheese and butter. Initially, butyrate (11) was described as an unusually potent inducer of erythroid differentiation in cultured erythroleukemic cells [96]. Treatment of cultured leukemia cells with butyrate (11) was then reported to inhibit classes I, IIa and IV HDAC activity, causing rapid histone hyperacetylation in leukemia cells [97].