Elsevier

Gynecologic Oncology

Volume 47, Issue 1, October 1992, Pages 53-57
Gynecologic Oncology

SGO article
Transition from benign to malignant epithelium in mucinous and serous ovarian cystadenocarcinoma

https://doi.org/10.1016/0090-8258(92)90075-TGet rights and content

Abstract

The slides of all patients with ovarian cystadenocarcinoma treated at the University of Kentucky Medical Center from 1966–1990 were reviewed. Fifty-four serous tumors and 42 mucinous neoplasms were identified for further study. Benign epithelium adjacent to an area of borderline or malignant epithelium was observed in 74 tumors (79%) and a site of epithelial transition was noted in 38 cases (40%). The presence of associated benign epithelium was more common in borderline or well-differentiated lesions and in patients with early-stage disease. These findings are consistent with epidemiologic and molecular genetic data and suggest that certain benign serous or mucinous ovarian tumors have the potential for malignant transformation. Removal of these tumors, particularly in postmenopausal women, should result in a subsequent reduction in the frequency of ovarian cancer.

References (19)

There are more references available in the full text version of this article.

Cited by (162)

  • Adnexal masses

    2023, DiSaia and Creasman Clinical Gynecologic Oncology
  • Progression of Cystadenoma to Mucinous Borderline Ovarian Tumor in Young Females: Case Series and Literature Review

    2022, Journal of Pediatric and Adolescent Gynecology
    Citation Excerpt :

    Benign lesions, BOTs, and invasive tumors frequently coexist in the same specimen.53 Ovarian epithelial neoplasms are often heterogeneous, with coexisting benign, borderline, and malignant components, a finding that is particularly frequent in mucinous tumors.37,54 The large size and heterogenous nature of mucinous carcinomas and their unilateral presentation underscore the fact that they grow slowly and potentially in a stepwise manner from benign and/or borderline precursors.55

  • Adnexal masses

    2018, Clinical Gynecologic Oncology
  • Ultrasound follow up of an adnexal mass has the potential to save lives

    2015, American Journal of Obstetrics and Gynecology
View all citing articles on Scopus

Presented at the 23rd Annual Meeting of the Society of Gynecologic Oncologists, San Antonio, TX, March 15–18, 1992.

1

American Cancer Society clinical career development awardee.

2

American Cancer Society professor of clinical oncology.

View full text