PaperThrombin enhances tumor cell adhesive and metastatic properties via increased αIIbβ3 expression on the cell surface
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Protein Z/protein Z-dependent protease inhibitor system in human non-small-cell lung cancer tissue
2012, Thrombosis ResearchCitation Excerpt :In NSCLC patients, activation of blood coagulation takes place not only intravascularly (leading to thromboembolic complications) but can proceeds extravascularly at the tumor site as well [1-7]. Thrombin and fibrin, formed as net products of blood coagulation, contribute to cancer cells proliferation, migration, local invasion, angiogenesis and distant metastases formation [3,9,28-31]. An important step in blood coagulation activation in malignancy is ascribed to factor X activation since multiple factors were demonstrated to trigger the reaction in cancer [3].
The platelet contribution to cancer progression
2011, Journal of Thrombosis and HaemostasisDeadly allies: The fatal interplay between platelets and metastasizing cancer cells
2010, BloodCitation Excerpt :The latter interesting effect might be explained, at least in part, by the observation that several tumor cell lines, including some melanoma cells, not only express tissue factor to activate thrombin, but also PAR receptors, a phenotype that appears to be associated with a higher metastatic potential.83-85 PAR-1 activation in tumor cells stimulates the expression of adhesion molecules, such as integrins αIIbβ3, αVβ5, or αVβ3.86-88 Thrombin-activated tumor cells not only interact with platelets in a stronger way than nonactivated cells but also show a greater capacity for adhering to endothelial cells in vitro.89-91
Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis
2009, Journal of Biological ChemistryCitation Excerpt :However, our data also suggest that MUC18 collaborates with other downstream targets of PAR1 to stimulate melanoma metastasis. Other surface adhesion proteins and vascular permeability factors that have been shown to influence tumor-to-endothelial cell adhesion and diapedesis include N-cadherin, Thomsen-Friedenreich glycoantigen and galectin-3, integrins α4β1, α5β1, and α3β2, P-selectin, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, vascular endothelial growth factor, and transforming growth factor-β (22, 53–57). However, whether or not some of these mediators are downstream targets of PAR1 in melanoma has not been yet investigated.
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On leave from Department of Hematology, Medical Academy, Bialystok, Poland