Elsevier

Thrombosis Research

Volume 58, Issue 4, 15 May 1990, Pages 355-366
Thrombosis Research

Paper
The concentration of tissue plasminogen activator and urokinase in plasma and tissues of patients with ovarian and uterine tumors

https://doi.org/10.1016/0049-3848(90)90207-SGet rights and content

Abstract

The concentrations of tissue plasminogen actiator (t-PA) and urokinase (UK) were measured in the plasma of patients with benign or malignant ovarian and uterine tumors. Plasma levels of t-PA were higher in patients with malignant ovarian and uterine tumors than in patients with benign tumors. Plasma UK levels were, however, not different between patients with ovarian and uterine tumors (benign or malignant) and normal persons. The concentrations of t-PA and UK of tissues of uterine myoma were lower than those in normal uterine muscular layer. UK levels of tissues of endometrial and cervical cancers were significantly higher than those in normal endometrium and uterine cervix, whereas t-PA levels were not different between these tumors compared with those in normal uterine tissues.

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  • Steady states and dynamics of urokinase-mediated plasmin activation in silico and in vitro

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    The PLS concentrations that show bistability in simulations (0.03–0.05 μM) would be reasonable in vivo because the total pool of PLS plus PLG was previously measured to be 0.5–2 μM (37–40). The level of scUPA needed to cause a state transition in simulations (0.7μM) is significantly above the empirical range of 0.1 nM to 0.1 μM measured for total urokinase (tcUPA plus scUPA) (41–44). Many factors could be responsible for the difference between simulated and measured urokinase values, including the greater activity of tcUPA compared with scUPA, different tissue types, and different measurement methods.

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