Original contributionInsulin-like growth factor 2 and insulin-like growth factor binding protein 2 expression in hepatoblastoma
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Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes
2021, Cell ReportsCitation Excerpt :Wilms tumor and hepatoblastoma display molecular defects consistent with IGF2 overexpression, such as loss of imprinting in the 11p15 region (Honda et al., 2008; Montagna et al., 1994; Rainier et al., 1995; Taniguchi et al., 1995). Overexpression of IGF2 was also detected in those tumors (Akmal et al., 1995; Scott et al., 1985). The tumor risk in BWS is the highest in patients with molecular defects that predict IGF2 overexpression (28% in patients with ICR1 GOM and 16% in patients with upd(11)pat) but low in patients with other molecular defects (2.6% in patients with ICR2 loss of methylation) (Maas et al., 2016; Mussa et al., 2016).
Preoperative plasma IGFBP2 is associated with nodal metastasis in patients with penile squamous cell carcinoma
2019, Urologic Oncology: Seminars and Original InvestigationsCitation Excerpt :Insulin-like growth factor-binding protein 2 (IGFBP2) is a member of a family of 6 highly conserved IGFBPs that are carriers for the insulin-like growth factors (IGFs). IGFBP2 contains RGD and HBD motifs which can directly bind to integrins and extracellular matrix and induce diverse biological actions independent of IGFs [13]. Recently, high serum/plasma IGFBP2 has been shown to be associated with poor clinical outcome in various solid malignancies, and is being evaluated as a potential cancer biomarker [14–19].
IGF binding protein 2 supports the survival and cycling of hematopoietic stem cells
2011, BloodCitation Excerpt :In addition to its expression during embryonic development and in normal adulthood, IGFBP2 is overexpressed in many tumors and its expression appears to correlate with the grade of malignancy.9-11 The level of IGFBP2 is low in well-differentiated tumors but high in poorly differentiated tumors.12 In the hematopoietic system, a lower IGFBP2 level is associated with the survival of patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL)28,29 and the expression of IGFBP2 is an independent factor for the prediction of relapse of AML and ALL.28,30-32
Cellular signaling, AGE accumulation and gene expression in hepatocytes of lean aging rats fed ad libitum or food-restricted
2002, Mechanisms of Ageing and DevelopmentComplex rearrangement of chromosomes 6 and 11 as the sole anomaly in atypical teratoid/rhabdoid tumors of the central nervous system
2000, Cancer Genetics and Cytogenetics