The conversion of androstenedione to estrone, estradiol, and testosterone in breast tissue☆
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2020, Environment InternationalCitation Excerpt :The LLODs of TT, E2 and SHBG were 0.75 ng/mL, 2.994 pg/m and 0.800 nmol/l, respectively. We also calculated a free androgen index (FAI) as the value of TT (ng/dL) divided by SHBG (nmol/L) and the ratio of TT to E2 (TT/E2) to indirectly assess the approximate amount of circulating free testosterone (WIlke and Utley, 1987) and the activity of aromatase (Perel et al., 1980), respectively. Because sex hormone levels varied dramatically by sex and developmental stages, we calculated the descriptive statistics and performed stratified analyses by age groups (children: 6–11 years, vs adolescents: 12–19 years) in both males and females.
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Part of this paper was presented at the 60th Annual Meeting of the Endocrine Society, Miami, 1978. This work was supported by a grant from The Medical Research Council of Canada MA 6251 and by a grant from the National Cancer Institute of Canada.