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CLIC1 a novel biomarker of intraperitoneal metastasis in serous epithelial ovarian cancer

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Tumor Biology

Abstract

Early diagnosis of intraperitoneal metastasis is a pivot for survival of patients with serous epithelial ovarian cancers (SEOC). However, to date, there is lack of efficient molecular biomarker for early metastasis of SEOC. Here, we found that the expression of chloride intracellular channel 1 (CLIC1) is highly correlative with intraperitoneal metastasis. There is very low expression of CLIC1 in normal ovaries (NO), benign ovarian tumor (BOT), and primary ovarian cancer without metastasis (POCNM); but its expression is remarkably high in primary ovarian cancer with metastasis (POCM) omentum and peritoneal metastasis. Furthermore, for clinic prediction of intraperitoneal metastasis of SEOC, the sensitivity and specificity of CLIC1 overexpression were 97.4 and 88.1 %, respectively. Collectively, CLIC1 may be a potential sensitive and specific molecular biomarker for early diagnose for SEOC metastasis.

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Acknowledgments

The authors thank all the people and patients who had predicated in this study.

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    Authors and Affiliations

    1. Department of Gynecology Oncology, The Tumor Affiliated Hospital of Harbin Medical University, Harbin, China

      Yuguang Ye, Mingzhu Yin & Ge Lou

    2. Department of Pathology, Yale School of Medicine, New Haven, CT, USA

      Mingzhu Yin, Yaqi Wang & Xia Li

    3. Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA

      Bihui Huang

    4. Department of Gynecology, The Tumor Hospital of Harbin Medical University, Harbin, 150086, China

      Ge Lou

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    1. Yuguang Ye
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    2. Mingzhu Yin
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    3. Bihui Huang
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    4. Yaqi Wang
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    5. Xia Li
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    6. Ge Lou
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    Corresponding author

    Correspondence to Ge Lou.

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    Mingzhu Yin is a joint first author and the two authors contributed equally to this work.

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    Ye, Y., Yin, M., Huang, B. et al. CLIC1 a novel biomarker of intraperitoneal metastasis in serous epithelial ovarian cancer. Tumor Biol. 36, 4175–4179 (2015). https://doi.org/10.1007/s13277-015-3052-8

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    • DOI: https://doi.org/10.1007/s13277-015-3052-8

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