Abstract
A strong link between inflammation and gastrointestinal cancer has been demonstrated. Interleukin (IL)-32 is a recently described pro-inflammatory cytokine characterized by the induction of nuclear factor kappa B (NF-κB) activation. We investigated whether IL-32 expression has clinical significance in gastric cancer. A total of 182 gastric cancer patients who received curative gastrectomy were enrolled in our study. IL-32 expression was detected by immunohistochemistry, and the correlation between clinicopathological features and IL-32 expression was analyzed. Tumor depth and lymph node metastases developed more frequently in IL-32-positive gastric cancer patients than those who were negative for IL-32 expression (p < 0.01). Lymphatic- and venous invasion in the IL-32-positive group were more severe than in cancer cells lacking IL-32 expression (p < 0.05). Multivariate analysis demonstrated that IL-32 is one of the prognostic markers (p < 0.03) for gastric cancer, in addition to nodal involvement and tumor depth. IL-32 positivity significantly affected clinicopathological factors. Thus, IL-32 expression in gastric cancer may serve as a preferential metastatic condition that allows cells to escape host antitumor immunity. Pro-inflammatory cytokines induce immunosuppression in a paracrine manner, thereby facilitating the metastasis of tumor cells.
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Acknowledgments
This study was supported by Grant-in-Aid for Scientific Research (KAKENHI) (No 21591707). The authors would like to thank the pathologists for their valuable technical assistance and facilitating the collection of patient information.
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The authors declare that they have no conflict of interest.
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Ishigami, S., Arigami, T., Uchikado, Y. et al. IL-32 expression is an independent prognostic marker for gastric cancer. Med Oncol 30, 472 (2013). https://doi.org/10.1007/s12032-013-0472-4
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DOI: https://doi.org/10.1007/s12032-013-0472-4