Abstract
Purpose
The aim of this study was to clarify the reliability of positron emission tomography (PET) using a new hypoxic cell tracer, 1-(2-[18F]fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole (18F-FRP170).
Procedures
Twelve patients with glioblastoma underwent 18F-FRP170 PET before tumor resection. Mean standardized uptake value (SUV) and normalized SUV were calculated at regions within a tumor showing high (high-uptake area) and relatively low (low-uptake area) accumulations of 18F-FRP170. In these areas, intratumoral oxygen pressure (tpO2) was measured using microelectrodes during tumor resection.
Results
Mean tpO2 was significantly lower in the high-uptake area than in the low-uptake area. A significant negative correlation was evident between normalized SUV and tpO2 in the high-uptake area.
Conclusion
The present findings suggest that high accumulation on 18F-FRP170 PET represents viable hypoxic tissues in glioblastoma.
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Abbreviations
- Cu-ATSM:
-
64Cu-diacetyl-bis(N4-methylthiosemicarbazone)
- 18F-FRP170:
-
1-(2-[18F]fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole
- 18F-FAZA:
-
1-α-d-(5-deoxy-5-5-[18F]-fluoroarabinofuranosyl)-2-nitroimidazole
- 18F-FMISO:
-
[18F]fluoromisonidazole
- Gd-T1WI:
-
Gadolinium-enhanced T1-weighted imaging
- HIF:
-
Hypoxic-inducible factor
- MRI:
-
Magnetic resonance imaging
- ROI:
-
Region of interest
- T2WI:
-
T2-weighted imaging
- PET:
-
Positron emission tomography
- VEGF:
-
Vascular endothelial growth factor
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Acknowledgments
This study was supported in part by Grant-in-Aid for Strategic Medical Science Research Center for Advanced Medical Science Research from the Ministry of Science, Education, Sports and Culture, Japan.
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The authors declare that they have no conflicts of interest.
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Beppu, T., Terasaki, K., Sasaki, T. et al. Standardized Uptake Value in High Uptake Area on Positron Emission Tomography with 18F-FRP170 as a Hypoxic Cell Tracer Correlates with Intratumoral Oxygen Pressure in Glioblastoma. Mol Imaging Biol 16, 127–135 (2014). https://doi.org/10.1007/s11307-013-0670-7
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DOI: https://doi.org/10.1007/s11307-013-0670-7