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Normal levels of serum IGF-I: determinants and validity of current reference ranges

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Abstract

Insulin like growth factor I (IGF-I) represents the key marker for the evaluation of Growth hormone (GH) status. As a large number of determinants including age, gender, genetic factors, nutrition, and disease states influence IGF-I serum levels, accurate normative data are essential to translate patient data into diagnostic meaning or even use IGF-I levels for adequate monitoring of patients with an over- or under-active GH axis. Even though reference ranges have been developed in large cohorts of healthy subjects, the dependency of these data on a given assay technology argues for assay specific normative data for IGF-I.

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Authors and Affiliations

  1. Department of Endocrinology, Christie Hospital, Wilmslow Rd, Manchester, M20 4BX, UK

    G. Brabant

  2. Department of Gastroenterology, Endocrinology and Nutrition, University of Greifswald, Greifswald, Germany

    H. Wallaschofski

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  1. G. Brabant
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  2. H. Wallaschofski
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Correspondence to G. Brabant.

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Brabant, G., Wallaschofski, H. Normal levels of serum IGF-I: determinants and validity of current reference ranges. Pituitary 10, 129–133 (2007). https://doi.org/10.1007/s11102-007-0035-9

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  • DOI: https://doi.org/10.1007/s11102-007-0035-9

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