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Dietary Factors Modifying Breast Cancer Risk and Relation to Time of Intake

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Journal of Mammary Gland Biology and Neoplasia Aims and scope Submit manuscript

Abstract

Multiple factors contribute to the development of human breast cancer. However, environmental factors, especially dietary factors, appear to have the greatest effects. Evidence obtained in epidemiological studies has been corroborated by laboratory findings. Dietary components strongly associated with breast cancer include fat and phytochemicals. A diet high in n-3 polyunsaturated fatty acid (PUFA) or monounsaturated fatty acid (MUFA) and low in n-6 PUFA is protective against breast cancer. Some phytochemicals present in fruits and vegetables are also protective. Time of intake appears to be important: lifetime protection may be achieved if one is exposed to a dietary factor that lowers breast cancer risk early in life. Synergistic and antisynergistic interactions between dietary factors can modify breast cancer risk. The available evidence suggests that breast cancer risk can be reduced by early dietary intervention.

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Abbreviations

CDHA:

conjugated docosahexaenoic acid

CLA:

conjugated linoleic acid

DADS:

diallyl disulfide

DHA:

docosahexaenoic acid

DMBA:

7,12-dimethylbenz(α) anthracene

EGFR:

epidermal growth factor receptor

EPA:

eicosapentaenoic acid

ER:

estrogen receptor

LA:

linoleic acid

MNU:

N-methyl-N-nitrosourea

MUFA:

monounsaturated fatty acid

OA:

oleic acid

PCNA:

proliferating cell nuclear antigen

PgR:

progesterone receptor

PhIP:

2-amino-1-methyl- 6-phenylimidazo [4-5-b] pyridine

POH:

perillyl alcohol

PUFA:

polyunsaturated fatty acid

SDG:

secoisolariciresinol diglycoside

SFA:

saturated fatty acid

TEB:

terminal end bud

TGF:

transforming growth factor

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Authors and Affiliations

  1. Department of Pathology II, Kansai Medical University, Moriguchi, Osaka, Japan

    Airo Tsubura, Norihisa Uehara, Yasuhiko Kiyozuka & Nobuaki Shikata

  2. Department of Pathology II, Kansai Medical University, Moriguchi, Osaka, 570-8506, Japan

    Airo Tsubura

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  1. Airo Tsubura
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  2. Norihisa Uehara
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  3. Yasuhiko Kiyozuka
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  4. Nobuaki Shikata
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Correspondence to Airo Tsubura.

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Tsubura, A., Uehara, N., Kiyozuka, Y. et al. Dietary Factors Modifying Breast Cancer Risk and Relation to Time of Intake. J Mammary Gland Biol Neoplasia 10, 87–100 (2005). https://doi.org/10.1007/s10911-005-2543-4

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