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Emerging Theranostic Gold Nanomaterials to Combat Lung Cancer: A Systematic Review

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Abstract

Lung cancer remains the significant cause of deaths in males and females worldwide and many attempts have been made for diagnosis and treatment of lung cancer. Nanotechnology has emerged as a novel strategy to design smart nanostructure weapons to combat lung cancer. Recently, the biogenic gold nanoparticles (AuNPs) have attracted highlighted interest for lung cancer theranostics. The current systematic review served to evaluate the anticancer potential of biologically synthesized AuNPs against lung cancer cells through in vitro studies. We provided valuable information regarding the efficacy of biogenic AuNPs suggesting their potential for next generation of anticancer drugs. The articles were identified through international databases involving Cochrane, Web of Science, PubMed, Scopus, Science Direct, ProQuest, and Embase. Eighteen articles were found eligible to enter into the current study. Our findings represented that although some studies reported nontoxicity of biogenic AuNPs against lung cancer cells, most of the studies reported significant anticancer activity of these nanoparticles (NPs) against lung cancer cells. Although the in vitro studies provided preliminary evidence for lung anticancer potential of biogenic AuNPs, further in vivo investigations are required to confirm the efficacy of these NPs through animal models.

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Acknowledgements

This work was financially supported by Shahid Beheshti University of Medical Sciences, Tehran, Iran (Grant Number 18753).

Author information

Authors and Affiliations

  1. Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Hamed Barabadi & Hossein Vahidi

  2. Golestan University of Medical Sciences, Food and Drug Administration, Gorgan, Iran

    Kaveh Damavandi Kamali

  3. Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Omid Hosseini

  4. Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammad Ali Mahjoub

  5. Student Research Committee, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran

    Masoumeh Rashedi

  6. School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Fereshteh Jazayeri Shoushtari

  7. Department of Medical Microbiology and Immunology, Division of Biomedical Sciences, School of Medicine College of Health Sciences, Mekelle University, 1871, Mekelle, Ethiopia

    Muthupandian Saravanan

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  1. Hamed Barabadi
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  8. Muthupandian Saravanan
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Correspondence to Hamed Barabadi, Masoumeh Rashedi or Muthupandian Saravanan.

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Barabadi, H., Vahidi, H., Damavandi Kamali, K. et al. Emerging Theranostic Gold Nanomaterials to Combat Lung Cancer: A Systematic Review. J Clust Sci 31, 323–330 (2020). https://doi.org/10.1007/s10876-019-01650-4

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