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Expression and Prognostic Significance of CD151, c-Met, and Integrin alpha3/alpha6 in Pancreatic Ductal Adenocarcinoma

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Abstract

Background

CD151, c-Met, and integrin alpha3/alpha6 are all involved in the hepatocyte growth factor (HGF)/c-Met signal pathway, which plays an important role in the malignant progression of tumors.

Aims

The purpose of this study was to explore the expression and prognostic significance of these proteins in pancreatic ductal adenocarcinoma (PDAC).

Methods

We used immunohistochemical methods to investigate the expression patterns of CD151, c-Met, and integrin alpha3/alpha6proteins in 71 patients with PDAC and in ten samples of normal pancreatic tissue. We also assessed correlations between these proteins and clinicopathological parameters and survival of PDAC patients using various statistical methods.

Results

CD151, c-Met, and integrin alpha3/alpha6 were all overexpressed in PDAC. CD151 and c-Met overexpressions were significantly associated with TNM stage (p = 0.001 and p = 0.038, respectively) and lymph node invasion (p = 0.000, p = 0.012, respectively). A significant positive linear correlation was found between CD151 and c-Met (r = 0.583; p = 0.000), integrin alpha3 (r = 0.457; p = 0.000), and integrin alpha6 (r = 0.671; p = 0.000). Overexpression of CD151, c-Met, integrin alpha3, or integrin alpha6 was related to poor survival of PDAC patients (p = 0.000, p = 0.000, p = 0.005, and p = 0.003, respectively), and CD151 and c-Met were independent factors in prognosis of PDAC.

Conclusions

CD151, c-Met, and integrin alpha3/alpha6 were all overexpressed in PDAC. CD151 and c-Met might be new molecular markers to predict the prognosis of PDAC patients.

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Acknowledgments

This work was supported by a grant (No. 09QA1404600) from the Science and Technology Commission of Shanghai Municipality awarded to the Department of Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University.

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Authors and Affiliations

  1. Department of General Surgery, Affiliated First People’s Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China

    Guang-Hui Zhu, Chen Huang, Zheng-Jun Qiu, Jun Liu, Zhi-Hua Zhang & Ning Zhao

  2. Department of Clinical Pathology, Affiliated First People’s Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China

    Zheng-Zhong Feng & Xiu-Hong Lv

  3. Department of Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University, 200080, Shanghai, China

    Guang-Hui Zhu, Chen Huang, Zheng-Jun Qiu & Jun Liu

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  1. Guang-Hui Zhu
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Correspondence to Zheng-Jun Qiu.

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Guang-Hui Zhu and Chen Huang contributed equally to this work.

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Zhu, GH., Huang, C., Qiu, ZJ. et al. Expression and Prognostic Significance of CD151, c-Met, and Integrin alpha3/alpha6 in Pancreatic Ductal Adenocarcinoma. Dig Dis Sci 56, 1090–1098 (2011). https://doi.org/10.1007/s10620-010-1416-x

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