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Hypoxia, gene expression, and metastasis

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Abstract

Hypoxia poses many problems to the treatment of cancer. Hypoxic tumors are more resistant to chemotherapy and radiation. In addition, hypoxia induces a number of genes responsible for increased invasion, aggressiveness, and metastasis of tumors. The augmented metastatic potential due to hypoxia-mediated gene expression is discussed in this section. Particular attention is given to recent studies of specific genes involved in the key steps of metastasis, including extracellular matrix interactions, migration, and proliferation.

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  1. Department of Radiation Oncology, Division of Cancer and Radiation Biology, Stanford University School of Medicine, CCSR-South, Room 1255, 269 Campus Drive, Stanford, CA, 94305-5152, USA

    Denise A. Chan & Amato J. Giaccia

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Correspondence to Amato J. Giaccia.

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Chan, D.A., Giaccia, A.J. Hypoxia, gene expression, and metastasis. Cancer Metastasis Rev 26, 333–339 (2007). https://doi.org/10.1007/s10555-007-9063-1

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