Abstract
Head and neck cancer comprises squamous cell carcinomas of the upper aerodigestive tract. There are similarities in their natural history, epidemiology and control. For these cancers premalignant changes can be identified. Smoking and drinking are the major risk factors. The geographical variations in incidence and mortality are indicative of differences in the prevalence of risk factors between countries. The dramatic increase in head and neck cancers is cause for great concern, particularly in Central-Eastern Europe. The great majority of these cancers could be prevented by reducing the prevalence of established risk factors. Screening could be used to detect both precancerous lesions and early invasive cancers; however, no study as yet has demonstrated a reduced incidence and mortality resulting from screening. When setting strategies for prevention, the socioeconomic differentials in incidence and mortality from head and neck cancers need to be taken into account.
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References
Shermann CD Jr: Cancer of the head and neck. In: Manual of Clinical Oncology. UICC, Springer, 1990
IARC: Tobacco Smoking. IARC Monograph on the Evaluation of the Carciniogenic Risk of Chemicals to Humans, Vol. 38. Lyon, IARC Press, 1986
International Agency for Research on Cancer: Cancer in the European Union in 1990. Lyon, IARC, 1996
Schwartz SM, Daling JR, Doody DR, Wipf GC, Carter JJ, Madeleine MM, Mao EJ, Fitzgibbons ED, Huang S, Beckmann AM, McDougall JK, Galloway DA: Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. J Natl Cancer Inst 90: 1626–1636, 1998
Bray F, Sankila R, Ferlay J, Parkin DM: Estimates of cancer incidence and mortality in Europe in 1995. Eur J Cancer 38: 99–166, 2002
Tuyns AJ, Esteve J, Raymond L, Berrino F, Benhamou E, Blanchet F, Boffetta P, Crosignani P, del Moral A, Lehmann. Cancer of the larynx/hypopharynx, tobacco and alcohol: IARC international case-control study in Turin and Varese (Italy), Zaragoza and Navarra (Spain), Geneva (Switzerland) and Calvados (France). Int J Cancer 41: 483–491, 1988.
Stewart BW, Kleihues P (eds): World Cancer Report, WHO International Agency for Research on Cancer, IARC Press, Lyon, 2003
Winn DM: Epidemiology of cancer and other systemic effects associated with the use of smokeless tobacco. Adv Dent Res 11: 313–321, 1997
La Vecchia C, Tavani A, Franchesci S, Levi F, Corrao G, Negri E: Epidemiology and prevention of oral cancer. Oral Oncol 33: 302–312, 1997
World Cancer Research Fund: Food, Nutrition and Prevention of Cancer: A Global Perspective. Washington, 1997
Sanchez MJ, Martinez C, Nieto A, Castellsague X, Quintana MJ, Bosch FX, Munoz N, Herrero R, Franceschi S: Oral and oropharyngeal cancer in Spain: Influence of dietary patterns. Eur J Cancer Prev 12: 49–56, 2003
Winn DM: Diet and nutrition in the etiology of oral cancer. Am J Clin Nutr 61: 437S–445S, 1995
Zheng TZ, Boyle P, Hu HF, Duan J, Jian PJ, Ma DQ, Shui LP, Niu SR, Scully C, MacMahon B: Dentition, oral hygiene, and risk of oral cancer: A case-control study in Beijing. Cancer Causes Control 1: 235–241, 1990
Homann N, Tillonen J, Rintamaki H, Salaspuro M, Lindqvist C, Meurman JH: Poor dental status increases acetaldehyde-production from ethanol in saliva: A possible link to increased oral cancer risk in heavy drinkers. Oral Oncol 37: 153–158, 2001
Bosch FX, Lorincz A, Munoz N, Meijer W, Shah KV: The causal relation between HPV and cervical cancer. J Clin Patol 55: 244–265, 2002
Mork J, Lie AK, Glattre E, Hallmans G, Jellum E, Koskela P, Moller B, Pukkala E, Schiller JT, Youngman L, Lehtinen M, Dillner J. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N Engl J Med 344: 1125–1131, 2001
Shah KV. Do human papillomavirus infections cause oral cancer? J Natl Cancer Inst 90: 1585–1586, 1998
Herrero R, Castellsagué X, Pawlita M, Lissowska J, Kee F, Balaram P, Rajkumar T, Sridhar H, Rose B, Pintos J, Fernández L, Idris A, Sánchez MJ, Nieto A, Talamini R, Tavani A, Bosch FX, Reidel U, Snijders PJF, Meijer CJLM, Viscidi R, Muñoz N, Franceschi S, For the IARC Multicenter Oral Cancer Study Group: Human Papillomavirus and oral cancer: The international agency for research on cancer multicenter study. J Natl Cancer Inst 95: 1772–1783, 2003
Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, WUL, Zahurak ML, Daniel RW, Viglione M, Syncer DE, Shah KV, Sidransky D: Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 92: 709–720, 2000
Shah JP, Johnson NW, Batsakus JG: Oral cancer. Martin Dunitz, London, 2003
Wake M: The urban/rural divide in head and neck cancer — the effect of atmospheric pollution. Otolaryngol 18: 298–302, 1993
Axell T, Holmstrup P, Kramer IRH, Pindborg JJ, Shear M: International seminar on oral leukoplakia and associated lesions related to tobacco habits. Community Dent Oral Epidemiol 12: 145–154, 1984
World Health Organization Collaborating Centre for Oral Precancerous Lesions. Definition of leukoplakia and related lesions: An aid to studies an oral precancer. Oral Surg Oral Med Oral Pathol 46: 518–539, 1978
Pindborg JJ: Clinical relevance of precancerous lesions of oral mucosa. In: Pape H-D, Gancer U, Schmitt G (eds) Carcinoma of Oral Cavity and Oropharynx. Springer-Verlag, Berlin, 1994, pp 9–16
Bánóczy J, Gintner Z, Dombi C: Tobacco use and oral lukoplakia. J Dent Educ 65: 322–327, 2001
Jaber MA, Porter SR, Gilthorpe MS, Bedi R, Scully C: Risk factors for oral epithelial dysplasia—the role of smoking and alcohol. Oral Oncol 35: 151–156, 1999
Bouquet JE, Gnepp DR: Laryngeal precancer: A review of the literature, commentary, and comparison with oral leukoplakia. Head and Neck 13: 488–497, 1991
Axell T: Occurrence of leukoplakia and some other oral white lesions among 20 333 adult Swedish people. Community Dent Oral Epidemiol 15: 46–51, 1987
Johnson NW, Ranasinghe AW, Warnakulasuriya KA: Potentially malignant lesions and conditions of the mouth and oropharynx: Natural history—cellular and molecular markers of risk. Eur J Cancer Prev 2 (Suppl): 31–51, 1993
Speight PM, Morgan PR: The natural history and pathology of oral cancer and precancer. Community Dental Health 10: 31–41, 1993
Axell T, Pindborg JJ, Smith CJ, van der Waal I: and an International collaborative group on oral white lesions. Oral white lesions with special references to precancerous and tobacco-related lesions; conclusions of an international symposium held in Uppsala, Sweden, May 18–21, 1994. J Oral Pathol Med 25: 49–54, 1996
Parkin DM, Chen VW, Ferlay J, Galceran J, Storm HH, Whelan SL (eds): Comparability and Quality Control in Cancer Registration. IARC Technical Report. No. 19, Lyon, IARC, 1998
Johnson NW: Tobacco use and oral cancer: A global perspective. J Dent Educ 65: 328–339, 2001
Kato I, Nomura AM. Alcohol in the aetiology of upper aero-digestive tract cancer. Eur J Cancer Oral Oncol 30B: 75–81, 1994
Franceschi S, Bidoli E, Herrero R, Munoz N: Comparison of cancers of the oral cavity and pharynx worldwide: Etiological clues. Oral Oncol 36: 106–115, 2000
Parkin DM, Pisani P, Ferlay I. Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer 54: 594–606, 1993
Plesko I, Macfarlane GJ, Evstifeeva TV, Obsitnikova A, Kramarova E: Oral and pharyngeal cancer incidence in Slovakia 1968–1989. Int J Cancer 56: 481–486, 1994
Llewellyn CD, Johnson NW, Warnakulasuriya KA. Risk factors for squamous cell carcinoma of oral cavity in young people—a comprehensive review. Oral Oncology 37: 401–418, 2001
Central Statistical Bureau. Demographic Yearbook 2001. Budapest 2002
Moore SR, Johnson NW, Pierce AM, Wilson DF: The epidemiology of mouth cancer: A review of global incidence. Oral Dis 6: 65–74, 2000
Páldy A, Nádor G, Vincze I, Zsámbokiné Bakacs M, Rajcsányi Á, Pintér A: Spacial differences in mortality and morbidity from cancer of the lip, oral cavity and pharynx in Hungary. Magyar Onkológia 45: 106–114, 2001. (in Hungarian)
Smans M, Muir CS, Boyle P: Atlas of cancer mortality in the European Economic Community. IARC Sci Publ. No. 107, Lyon, IARC, 1999
Zatonski W, Smans M, Tyczynski J, et al: Atlas of cancer mortality in Central Europe. IARC, Sci Publ No. 134, Lyon, IARC, 1996
Berrino F, Capocaccia I, Esteve J, Gatta G, Hakulinen T, Micheli A, Sa M (eds): Survival of cancer patients in Europe: The EUROCARE-2 study. IARC Sci. Publ. No. 1151, Lyon, IARC Press, 1999
Boyle P, Macfarlane GJ, Scully C: Oral cancer: Necessity for prevention strategies. Lancet 342: 1129, 1993
Chamberlain J, Moss S (eds): Evaluation of Cancer Screening. Springer, London, 1996
Remenár É: Proposal for screening of oral and oropharyngeal cancer in the population at risk. Magyar Onkológia (Hungarian Oncology) 45: 149–151, 2001. (in Hungarian)
Kogevinas M, Pearce N, Susser M, Boffetta P (eds): Social Inequalities and Cancer. IARC Sci Publ No 138, Lyon, IARC, 1997
Faggiano F, Partanen T, Kongevinas M, Boffetta P: Socioeconomic differences in cancer incidence and mortality. In: Kogevinas M, Pearce N, Susser M, et al. (eds): Social Inequalities and Cancer. IARC, Sci Publ No 138, Lyon, IARC 1997, pp 65–170
Kongevinas M, Porta M: Socioeconomic differences in cancer survival: A review of the evidence. In: Kogevinas M, Pearce N, Susser M, et al. (eds): Social Inequalities and Cancer. IARC Sci Publ No 138, Lyon, IARC 1997, pp 177–206
Möller H, Tönnesen H: Alcohol drinking, social class and cancer. In: Kogevinas M, Pearce N, Susser M, Boffetta P (eds): Social Inequalities and Cancer. IARC Sci Publ No 138, Lyon, IARC, 1997, pp 251–265
Stellman SD, Resnikow K: Tobacco smoking, cancer and social class. In: Kogevinas M, Pearce N, Susser M, et al. (eds): Social Inequalities and Cancer. IARC Sci Publ No 138. Lyon, IARC, 1997, pp 229–250
IARC: Alcohol Drinking. IARC Monograph on the Evaluation of the Carciniogenic Risk of Chemicals to Humans, Vol. 44. Lyon, IARC Press, 1988
Tomatis L (ed): Cancer: Causes, occurrence and control. IARC Scientific Publications No. 100, Lyon, IARC Press, 1990
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Döbróssy, L. Epidemiology of head and neck cancer: Magnitude of the problem. Cancer Metastasis Rev 24, 9–17 (2005). https://doi.org/10.1007/s10555-005-5044-4
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DOI: https://doi.org/10.1007/s10555-005-5044-4