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Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients

  • Epidemiology
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Abstract

The aim of this study is to estimate the frequency of pathologic complete response (pCR) after neoadjuvant treatment with cisplatin chemotherapy in women with breast cancer and a BRCA1 mutation. One hundred and seven women with breast cancer and a BRCA1 mutation, who were diagnosed with stage I to III breast cancer between December 2006 and June 2014, were treated with cisplatin 75 mg/m2 every 3 weeks for four cycles, followed by mastectomy and conventional chemotherapy. Information was collected on clinical stage, grade, hormone receptor status, and Her2neu status prior to treatment. pCR was determined by review of surgical specimens. One hundred and seven patients were enrolled in the study, including 93 patients who were treated for first primary breast cancer and 14 patients who had previously received treatment for a prior cancer. A pCR was observed in 65 of the 107 patients (61 %). Platinum-based chemotherapy is effective in a high proportion of patients with BRCA1-associated breast cancer.

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Acknowledgments

We would like to thank M. Siolek, M. Szwiec, H. Symonowicz, D. Surdyka, O. Ashuryk, B. Gorski, T. Debniak, D. Zuziak, and D. Sawka for helping to recruit patients to this study. We thank W. Domagala for the pathology review. We would also like to thank the Estee Lauder companies for their generous support on this project. The study is registered in the Clinical Trails gov, study number NCT01630226 and was by funded by Polish Ministry of Science; Grant No. PBZ-KBN-122 /po5/ 2004.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Oncology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland

    T. Byrski

  2. Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland

    T. Huzarski, J. Gronwald, C. Cybulski & J. Lubinski

  3. Sunnybrook Odette Cancer Center, Toronto, ON, Canada

    R. Dent

  4. Oncology Institute, Kraków, Poland

    E. Marczyk, M. Jasiowka & J. Jakubowicz

  5. Regional Oncology Center, Bielsko-Biala, Poland

    R. Wisniowski

  6. Center for Epidemiology and Prevention, Poznan, Poland

    D. Godlewski

  7. Women’s College Research Institute, 790 Bay Street, 7th Floor, Toronto, ON, M5G 1N8, Canada

    S. A. Narod

Authors
  1. T. Byrski
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  2. T. Huzarski
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  3. R. Dent
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  4. E. Marczyk
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  5. M. Jasiowka
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  6. J. Gronwald
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  7. J. Jakubowicz
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  8. C. Cybulski
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  9. R. Wisniowski
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  10. D. Godlewski
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  11. J. Lubinski
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  12. S. A. Narod
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Corresponding author

Correspondence to S. A. Narod.

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Byrski, T., Huzarski, T., Dent, R. et al. Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients. Breast Cancer Res Treat 147, 401–405 (2014). https://doi.org/10.1007/s10549-014-3100-x

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  • DOI: https://doi.org/10.1007/s10549-014-3100-x

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