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The role of cyclooxygenase-2 in breast cancer: review

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Abstract

There is a growing body of evidence that COX-2 expression s a fundamental step in breast cancer pathogenesis acting through prostaglandin-dependent and independent mechanisms. Epidemiological studies suggest that NSAIDs confer a moderate degree of benefit against breast cancer. However further work is required to establish how this enzyme system can be best manipulated for therapeutic benefit.

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Authors and Affiliations

  1. St George’s University of London, London, UK

    Gurpreet Singh-Ranger, Mohamed Salhab & Kefah Mokbel

  2. The London Breast Institute, The Princess Grace Hospital, 42-52 Nottingham Place, London, W1M 3FD, UK

    Kefah Mokbel

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  1. Gurpreet Singh-Ranger
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Singh-Ranger, G., Salhab, M. & Mokbel, K. The role of cyclooxygenase-2 in breast cancer: review. Breast Cancer Res Treat 109, 189–198 (2008). https://doi.org/10.1007/s10549-007-9641-5

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