Abstract
Purpose
Immunoglobulin (Ig)G4-related ophthalmic disease belongs to a category of ocular adnexal lymphoproliferative disorders, the most frequent group of orbital tumors and simulating lesions. The aim of this study was to elucidate the number of IgG4-related diseases of orbital lymphoproliferative disorders and correlate ages and sex of such patients from 18 centers in Japan.
Methods
One thousand and fourteen patients with orbital lymphoproliferative disorders were enrolled in this study. All had pathologically diagnosed lymphoproliferative disorders with surgical samples of ocular adnexal tissue. Patients with conjunctival lesions and intraocular lymphoma were excluded.
Results
Of the 1,014 cases of orbital lymphoproliferative disorders 404 (39.8 %) had extranodal mucosa-associated lymphoid tissue (MALT) lymphoma, 156 (15.4 %) had other malignant lymphomas, 191 (18.8 %) had non-IgG4 orbital inflammation, 219 (21.6 %) had IgG4-related orbital inflammation, and 44 (4.3 %) had IgG4-positive MALT lymphoma. Median age of the IgG4-related orbital inflammation group was 62 years, which is significantly lower than that of the MALT lymphoma group (median 66 years) and higher than the non-IgG4 orbital inflammation group (median 57 years). The male/female ratio was 105/114 in the IgG4-related orbital inflammation group.
Conclusions
Nearly a quarter of orbital lymphoproliferative disorders in Japan are related to IgG4.
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Members of the Japanese study group of IgG4-related ophthalmic disease are listed in the Appendix.
Appendix
Appendix
Study group investigators in the Japanese study of IgG4-related ophthalmic disease.
Aihara, Yukiko; Department of Ophthalmology, University of Tokyo School of Medicine
Azumi, Atsushi; Ophthalmology Department, Kobe Kaisei Hospital
Furuta, Minoru; Department of Ophthalmology, Fukushima Medical University School of Medicine
Goto, Hiroshi; Department of Ophthalmology, Tokyo Medical University Hospital
Hamaoka, Shoko; Department of Ophthalmology, Kanazawa University Graduate School of Medical Sciences
Hayashi, Kengo; Ocular Plastic and Orbital Surgery, Seirei Hamamatsu General Hospital
Hayashi, Nobutsugu; Section of Ophthalmology, Susaki Kuroshio Hospital
Kase, Satoru; Department of Ophthalmology, Hokkaido University Graduate School of Medicine
Kashima, Tomoyuki; Department of Ophthalmology, Gunma University of Medicine
Katori, Nobutada; Ocular Plastic and Orbital Surgery, Seirei Hamamatsu General Hospital
Konno, Kimihito; Kyorin Eye Center, Kyorin University School of Medicine
Kubota, Toshinobu; Department of Ophthalmology, National Hospital Organization Nagoya Medical Center
Obata, Hiroto; Department of Ophthalmology, School of Medicine, Jichi Medical University
Oguchi, Yasuharu; Department of Ophthalmology, Fukushima Medical University School of Medicine
Ohshima, Koh-ichi; Section of Ophthalmology, National Hospital Organization Okayama Medical Center
Oyama, Tokuhide; Department of Ophthalmology, Niigata University School of Medicine
Shikishima, Keigo; Department of Ophthalmology, Jikei University School of Medicine
Sogabe, Yuka; Department of Ophthalmology, Mitoyo General Hospital
Sugiyama, Kazuhisa; Department of Ophthalmology, Kanazawa University Graduate School of Medical Sciences
Takahira, Masayuki; Department of Ophthalmology, Kanazawa University Graduate School of Medical Sciences
Tsuji, Hideki; Department of Ophthalmology, The Cancer Institute Hospital of JFCR
Ueda, Shun-ichiro; Department of Ophthalmology, Tokyo Medical University Hospital
Yoshikawa, Hiroshi; Department of Ophthalmology, Kyushu University Graduate School of Medical Sciences
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Japanese study group of IgG4-related ophthalmic disease. A prevalence study of IgG4-related ophthalmic disease in Japan. Jpn J Ophthalmol 57, 573–579 (2013). https://doi.org/10.1007/s10384-013-0266-4
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DOI: https://doi.org/10.1007/s10384-013-0266-4