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A prevalence study of IgG4-related ophthalmic disease in Japan

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Abstract

Purpose

Immunoglobulin (Ig)G4-related ophthalmic disease belongs to a category of ocular adnexal lymphoproliferative disorders, the most frequent group of orbital tumors and simulating lesions. The aim of this study was to elucidate the number of IgG4-related diseases of orbital lymphoproliferative disorders and correlate ages and sex of such patients from 18 centers in Japan.

Methods

One thousand and fourteen patients with orbital lymphoproliferative disorders were enrolled in this study. All had pathologically diagnosed lymphoproliferative disorders with surgical samples of ocular adnexal tissue. Patients with conjunctival lesions and intraocular lymphoma were excluded.

Results

Of the 1,014 cases of orbital lymphoproliferative disorders 404 (39.8 %) had extranodal mucosa-associated lymphoid tissue (MALT) lymphoma, 156 (15.4 %) had other malignant lymphomas, 191 (18.8 %) had non-IgG4 orbital inflammation, 219 (21.6 %) had IgG4-related orbital inflammation, and 44 (4.3 %) had IgG4-positive MALT lymphoma. Median age of the IgG4-related orbital inflammation group was 62 years, which is significantly lower than that of the MALT lymphoma group (median 66 years) and higher than the non-IgG4 orbital inflammation group (median 57 years). The male/female ratio was 105/114 in the IgG4-related orbital inflammation group.

Conclusions

Nearly a quarter of orbital lymphoproliferative disorders in Japan are related to IgG4.

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Additional information

Members of the Japanese study group of IgG4-related ophthalmic disease are listed in the Appendix.

Appendix

Appendix

Study group investigators in the Japanese study of IgG4-related ophthalmic disease.

Aihara, Yukiko; Department of Ophthalmology, University of Tokyo School of Medicine

Azumi, Atsushi; Ophthalmology Department, Kobe Kaisei Hospital

Furuta, Minoru; Department of Ophthalmology, Fukushima Medical University School of Medicine

Goto, Hiroshi; Department of Ophthalmology, Tokyo Medical University Hospital

Hamaoka, Shoko; Department of Ophthalmology, Kanazawa University Graduate School of Medical Sciences

Hayashi, Kengo; Ocular Plastic and Orbital Surgery, Seirei Hamamatsu General Hospital

Hayashi, Nobutsugu; Section of Ophthalmology, Susaki Kuroshio Hospital

Kase, Satoru; Department of Ophthalmology, Hokkaido University Graduate School of Medicine

Kashima, Tomoyuki; Department of Ophthalmology, Gunma University of Medicine

Katori, Nobutada; Ocular Plastic and Orbital Surgery, Seirei Hamamatsu General Hospital

Konno, Kimihito; Kyorin Eye Center, Kyorin University School of Medicine

Kubota, Toshinobu; Department of Ophthalmology, National Hospital Organization Nagoya Medical Center

Obata, Hiroto; Department of Ophthalmology, School of Medicine, Jichi Medical University

Oguchi, Yasuharu; Department of Ophthalmology, Fukushima Medical University School of Medicine

Ohshima, Koh-ichi; Section of Ophthalmology, National Hospital Organization Okayama Medical Center

Oyama, Tokuhide; Department of Ophthalmology, Niigata University School of Medicine

Shikishima, Keigo; Department of Ophthalmology, Jikei University School of Medicine

Sogabe, Yuka; Department of Ophthalmology, Mitoyo General Hospital

Sugiyama, Kazuhisa; Department of Ophthalmology, Kanazawa University Graduate School of Medical Sciences

Takahira, Masayuki; Department of Ophthalmology, Kanazawa University Graduate School of Medical Sciences

Tsuji, Hideki; Department of Ophthalmology, The Cancer Institute Hospital of JFCR

Ueda, Shun-ichiro; Department of Ophthalmology, Tokyo Medical University Hospital

Yoshikawa, Hiroshi; Department of Ophthalmology, Kyushu University Graduate School of Medical Sciences

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Japanese study group of IgG4-related ophthalmic disease. A prevalence study of IgG4-related ophthalmic disease in Japan. Jpn J Ophthalmol 57, 573–579 (2013). https://doi.org/10.1007/s10384-013-0266-4

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  • DOI: https://doi.org/10.1007/s10384-013-0266-4

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