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Immunohistochemical application of S100A1 in renal oncocytoma, oncocytic papillary renal cell carcinoma, and two variants of chromophobe renal cell carcinoma

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Abstract

S100A1 is a calcium-binding protein and a member of the S100 family. Recently, S100A1 immunohistochemistry may be an available marker in the differential diagnosis between renal oncocytoma and chromophobe renal cell carcinoma (RCC). However, there are no reports on S100A1 expression in oncocytic papillary RCC that has been recently identified. In this article, we immunohistochemically examined the expression of S100A1 protein in 18 renal tumors including 4 renal oncocytoma, 10 chromophobe RCCs, and 4 oncocytic papillary RCCs. All the cases of renal oncocytoma and oncocytic papillary RCC showed a positive reaction for S100A1 with cytoplasmic pattern. In chromophobe RCC, 3 of 4 tumors with typical variant and 4 of 6 tumors in eosinophilic variant were completely negative for S100A1. Finally, S100A1 immunohistochemistry may be useful in distinguishing renal oncocytoma from chromophobe RCC, but it may be of no use in the differential diagnosis between renal oncocytoma and oncocytic papillary RCC.

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Authors and Affiliations

  1. Department of Diagnostic Pathology, Kochi Red Cross Hospital, 2-13-51 Shin-honmachi, Kochi, 780-8562, Japan

    Naoto Kuroda

  2. Department of Pathology, Kawasaki Medical School, Okayama, Japan

    Naoki Kanomata

  3. Department of Pathology, Ayabe City Hospital, Kyoto, Japan

    Tadanori Yamaguchi

  4. Division of Surgical Pathology, University of Fukui Hospital, Fukui, Japan

    Yoshiaki Imamura

  5. Department of Pathology, Kansai Medical University Hirakata Hospital, Osaka, Japan

    Chisato Ohe & Noriko Sakaida

  6. Department of Pathology, Charles University Hospital Plzen, Plzen, Czech Republic

    Ondrej Hes & Michal Michal

  7. Department of Urology, Kochi Medical School, Kochi University, Kochi, Japan

    Taro Shuin

  8. Department of Pathology, Kochi Medical School, Kochi University, Kochi, Japan

    Gang-Hong Lee

Authors
  1. Naoto Kuroda
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  2. Naoki Kanomata
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  3. Tadanori Yamaguchi
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  4. Yoshiaki Imamura
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  5. Chisato Ohe
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  6. Noriko Sakaida
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  7. Ondrej Hes
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  8. Michal Michal
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  9. Taro Shuin
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  10. Gang-Hong Lee
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Correspondence to Naoto Kuroda.

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Kuroda, N., Kanomata, N., Yamaguchi, T. et al. Immunohistochemical application of S100A1 in renal oncocytoma, oncocytic papillary renal cell carcinoma, and two variants of chromophobe renal cell carcinoma. Med Mol Morphol 44, 111–115 (2011). https://doi.org/10.1007/s00795-009-0461-z

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  • DOI: https://doi.org/10.1007/s00795-009-0461-z

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