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Anti-prostate cancer activity of 8-hydroxyquinoline-2-carboxaldehyde-thiosemicarbazide copper complexes in vivo by bioluminescence imaging

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Abstract

Copper 8-hydroxyquinoline-2-carboxaldehyde-thiosemicarbazide complex (CuHQTS) is a copper complex with strong anticancer activity against cisplatin-resistant neuroblastoma and prostate cancer cells in vitro by cell proliferation assay or fluorescent microscopic imaging. This study aimed to evaluate anti-prostate cancer activity of CuHQTS in vivo by bioluminescence imaging (BLI) and tumor size measurement, using athymic nu/nu mice implanted with prostate cancer cells carrying luciferase reporter gene (Luc-PC3). Growth of Luc-PC3 cells (1 × 105 cells) implanted in athymic nu/nu mice treated with CuHQTS for 2 weeks was suppressed by measurement of luciferase signals (6.18 × 107 to 5.36 × 107 p/s/cm2/sr) with BLI, compared with luciferase signals of Luc-PC3 cells (4.66 × 107 to 1.51 × 108 p/s/cm2/sr, p < 0.05) in the mice treated with normal saline of placebo control. Moreover, the size of PC-3 xenograft tumor (126.5 ± 34.2 mm3) in athymic nu/nu mice treated with CuHQTS was significantly smaller than the size of PC-3 xenograft tumor (218.6 ± 48.0 mm3, p < 0.05) in athymic nu/nu mice treated with normal saline of placebo control, suggesting in vivo tumor growth inhibition activity of CuHQTS on prostate cancer. The findings of this study support further investigation of CuHQTS as a promising new anticancer agent for the treatment of metastatic prostate cancer refractory to anticancer drugs currently available.

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Acknowledgements

The authors thank Haiyuan Zhang for synthesis of CuHQTS used for this study. This study was supported by a faculty research development fund awarded to F. P by Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center for financial support. The study was also supported in part with infrastructure of the Southwestern Small Animal Imaging Resource provided by 1P30 CA142543 and P41-EB015908.

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Authors and Affiliations

  1. Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Fang Xie, Huawei Cai & Fangyu Peng

  2. PET Center, Huashan Hospital, Fudan University, Shanghai, 200235, China

    Fang Xie

  3. Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China

    Huawei Cai

  4. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Fangyu Peng

  5. Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Fangyu Peng

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  1. Fang Xie
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  2. Huawei Cai
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  3. Fangyu Peng
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Correspondence to Fangyu Peng.

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Xie, F., Cai, H. & Peng, F. Anti-prostate cancer activity of 8-hydroxyquinoline-2-carboxaldehyde-thiosemicarbazide copper complexes in vivo by bioluminescence imaging. J Biol Inorg Chem 23, 949–956 (2018). https://doi.org/10.1007/s00775-018-1596-y

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  • DOI: https://doi.org/10.1007/s00775-018-1596-y

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