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Characterization of novel bovine papillomavirus type 12 (BPV-12) causing epithelial papilloma

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Abstract

Bovine papillomavirus type 12 (BPV-12, putative type BAA1) was detected in epithelial papilloma located on the tongue of an infected cow. Then, the whole genome was sequenced, and phylogenetic analysis illustrated that it should be classified as a member of the genus Xipapillomavirus. The viral genome is 7197 base pairs in length and contains five early ORFs (E1, E2, E4, E7 and E8), three late ORFs (L1, L2 and L3), and a long control region that possesses replication regulatory elements. Meanwhile, mRNA of each gene was detected in the papilloma sample. The papilloma was identified as epithelial papilloma by histological and immunohistochemical examination. Based on the genome information and pathological properties, BAA1 was designated as BPV-12 in this study.

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Acknowledgments

This work was partly supported by the Project for Zoonoses Education and Research, University of Miyazaki, and by a grant from Japan Society for the Promotion of Science (No. KAKENHI22780272).

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Authors and Affiliations

  1. Department of Veterinary Microbiology, University of Miyazaki, 1-1 Gakuen Kibanadai Nishi, Miyazaki, 889-2192, Japan

    Wei Zhu, Jianbao Dong, Yoshitaka Goto & Takeshi Haga

  2. JSPS, The United Graduate School of Veterinary Science, Yamaguchi University, Chiyoda, Tokyo, 102-8472, Japan

    Jianbao Dong

  3. Miyazaki Prefecture Tsuno Meat Inspection Center, Tsuno, Miyazaki, 889-1201, Japan

    Erika Shimizu

  4. Hokkaido Research Station, National Institute of Animal Health, 4 Hitsujigaoka, Toyohira, Sapporo, 062-0045, Japan

    Shinichi Hatama & Koichi Kadota

Authors
  1. Wei Zhu
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  2. Jianbao Dong
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  3. Erika Shimizu
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  4. Shinichi Hatama
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  7. Takeshi Haga
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Correspondence to Takeshi Haga.

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W. Zhu and J. Dong contributed equally to this work.

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Zhu, W., Dong, J., Shimizu, E. et al. Characterization of novel bovine papillomavirus type 12 (BPV-12) causing epithelial papilloma. Arch Virol 157, 85–91 (2012). https://doi.org/10.1007/s00705-011-1140-7

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  • DOI: https://doi.org/10.1007/s00705-011-1140-7

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